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The Benevolent Bile: Bile Acids as Stimulants of Liver Regeneration.

作者信息

Bhushan Bharat, Apte Udayan

机构信息

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.

出版信息

Cell Mol Gastroenterol Hepatol. 2022;13(5):1478-1480. doi: 10.1016/j.jcmgh.2022.02.004. Epub 2022 Feb 14.

DOI:10.1016/j.jcmgh.2022.02.004
PMID:35176509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043297/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2014/9043297/f857ebcf23f8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2014/9043297/f857ebcf23f8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2014/9043297/f857ebcf23f8/gr1.jpg

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本文引用的文献

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Liver regeneration: biological and pathological mechanisms and implications.肝脏再生：生物学和病理学机制及其意义。
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):40-55. doi: 10.1038/s41575-020-0342-4. Epub 2020 Aug 6.
2
Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities.对乙酰氨基酚肝毒性后的肝脏再生：机制与治疗机会。
Am J Pathol. 2019 Apr;189(4):719-729. doi: 10.1016/j.ajpath.2018.12.006. Epub 2019 Jan 14.
3
Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury.
胆汁酸调节半胱氨酸分解代谢和谷胱甘肽再生，从而调节肝脏对氧化损伤的敏感性。
JCI Insight. 2018 Apr 19;3(8). doi: 10.1172/jci.insight.99676.
4
Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice.工程化成纤维细胞生长因子 19 可预防对乙酰氨基酚引起的肝损伤并刺激老年小鼠肝脏再生。
Cell Death Dis. 2017 Oct 5;8(10):e3083. doi: 10.1038/cddis.2017.480.
5
Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice.成纤维细胞生长因子 15 缺乏增加了对乙酰氨基酚诱导的肝损伤的易感性，但不能改善其修复。
Dig Liver Dis. 2018 Feb;50(2):175-180. doi: 10.1016/j.dld.2017.08.023. Epub 2017 Aug 12.
6
Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications.胆汁酸、FGF15/19 和肝再生：从机制到临床应用。
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1326-1334. doi: 10.1016/j.bbadis.2017.06.025. Epub 2017 Jul 12.
7
Bile acids and their receptors during liver regeneration: "Dangerous protectors".胆汁酸及其受体在肝再生中的作用：“危险的保护者”。
Mol Aspects Med. 2017 Aug;56:25-33. doi: 10.1016/j.mam.2017.03.002. Epub 2017 Mar 23.
8
Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer.胆汁酸在胆汁淤积、炎症和癌症中的代谢与信号传导
Adv Pharmacol. 2015;74:263-302. doi: 10.1016/bs.apha.2015.04.003. Epub 2015 May 27.
9
Bile acid flux is necessary for normal liver regeneration.胆汁酸流对于正常的肝脏再生是必要的。
PLoS One. 2014 May 19;9(5):e97426. doi: 10.1371/journal.pone.0097426. eCollection 2014.
10
Bile acids are nutrient signaling hormones.胆汁酸是营养信号激素。
Steroids. 2014 Aug;86:62-8. doi: 10.1016/j.steroids.2014.04.016. Epub 2014 May 10.