College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Poult Sci. 2022 Apr;101(4):101732. doi: 10.1016/j.psj.2022.101732. Epub 2022 Jan 15.
Itaconic acid (IA) is a biologically based unsaturated dicarboxylic acid secreted by mammalian cells. While IA has potential for use in multiple applications, information regarding the influence of IA on animal production remains scarce. This study investigated the effects of dietary IA supplementation on the growth performance, nutrient digestibility, slaughter variables, blood parameters, and intestinal morphology of broiler chickens. A total of 360 one-day-old Arbor Acre broiler chicks were allotted to 6 groups, with 10 chicks per cage and 6 replicates per group in a randomized complete block design. Broiler chicks were fed a basal diet with 0 (control), 0.2, 0.4, 0.6, 0.8, or 1.0% IA. The experimental period lasted from 1 to 42 d of age. Dietary IA supplementation did not affect average daily gain (ADG) and feed/gain ratio (F/G) but quadratically increased average daily feed intake (ADFI) and linearly increased crude protein (CP) digestibility during the grower period (d 22-42). A higher breast and thigh muscle yield and a lower abdominal fat yield were observed in a linear and quadratic manner with the IA supplementation. Adding IA to the diet had significant effects on superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and catalase (CAT) levels in serum at d 21 and on total antioxidation capacity (T-AOC) at d 42. There were linear and quadratic increases in villus height and the villus height/crypt depth ratio (V/C) of the duodenum and villus height of the jejunum with the supplementation of IA. Regression analyses for ADFI, dressed yield, breast and thigh muscle yield, abdominal fat yield, serum ALT, CAT, and SOD levels, villus length of the duodenum and jejunum, and V/C of the duodenum indicated that the optimal dietary IA supplementation would be from 0.4 to 0.7%. From an economic perspective, a level of 0.4% IA in the broiler diet is recommended for improving the nutrient digestibility, slaughter performance, antioxidant ability, and intestinal morphology of broiler chickens.
衣康酸（IA）是哺乳动物细胞分泌的一种生物基不饱和二羧酸。虽然 IA 具有多种应用的潜力，但关于 IA 对动物生产影响的信息仍然很少。本研究探讨了日粮 IA 补充对肉鸡生长性能、养分消化率、屠宰变量、血液参数和肠道形态的影响。将 360 只 1 日龄 Arbor Acre 肉鸡随机分成 6 组，每组 10 只鸡，每个重复 6 只鸡，采用完全随机区组设计。肉鸡饲喂基础日粮，对照组不添加 IA，0.2%、0.4%、0.6%、0.8%和 1.0% IA。试验期从 1 日龄至 42 日龄。日粮 IA 补充对平均日增重（ADG）和饲料/增重比（F/G）没有影响，但显著提高了平均日采食量（ADFI）和粗蛋白（CP）消化率（22-42 日龄），呈二次曲线关系。线性和二次添加 IA 可提高肉鸡的胸肌和腿肌产量，降低腹脂产量。日粮添加 IA 对 21 日龄血清中超氧化物歧化酶（SOD）、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）和过氧化氢酶（CAT）水平以及 42 日龄总抗氧化能力（T-AOC）有显著影响。IA 补充使十二指肠和空肠的绒毛高度和绒毛高度/隐窝深度比（V/C）以及空肠的绒毛高度呈线性和二次增加。ADFI、屠体产量、胸肌和腿肌产量、腹脂产量、血清 ALT、CAT 和 SOD 水平、十二指肠和空肠的绒毛长度以及十二指肠的 V/C 与 ADFI 的回归分析表明，日粮 IA 的最佳添加量为 0.4%至 0.7%。从经济角度来看，推荐肉鸡日粮中添加 0.4%的 IA，以提高肉鸡的养分消化率、屠宰性能、抗氧化能力和肠道形态。
