Liu Jinbao, Fakhar Ali Zeeshan, Pajerowska-Mukhtar Karolina M, Mukhtar M Shahid
Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.
Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.
Trends Plant Sci. 2022 May;27(5):426-429. doi: 10.1016/j.tplants.2022.01.011. Epub 2022 Feb 14.
Toll/interleukin-1 receptor (TIR) domain-containing proteins are conserved across kingdoms, and their mechanistic understanding holds promise for basic plant biology and agriculture. Here, we discuss the novel enzymatic TIR domain functions of nucleotide-binding leucine-rich repeat receptors (NLRs) in cell death, and posit how TIR domain-containing effectors mechanistically subvert host immune systems.
含Toll/白细胞介素-1受体（TIR）结构域的蛋白质在不同生物界中保守，对其作用机制的理解有望推动基础植物生物学和农业发展。在此，我们讨论了核苷酸结合富含亮氨酸重复序列受体（NLR）的新型酶促TIR结构域在细胞死亡中的功能，并推测含TIR结构域的效应蛋白如何在机制上颠覆宿主免疫系统。
