一场无休止的战斗：植物-病原体相互作用中的TIR结构域

A TIReless battle: TIR domains in plant-pathogen interactions.

作者信息

Liu Jinbao, Fakhar Ali Zeeshan, Pajerowska-Mukhtar Karolina M, Mukhtar M Shahid

机构信息

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

出版信息

Trends Plant Sci. 2022 May;27(5):426-429. doi: 10.1016/j.tplants.2022.01.011. Epub 2022 Feb 14.

DOI:10.1016/j.tplants.2022.01.011

PMID:35177315

Abstract

Toll/interleukin-1 receptor (TIR) domain-containing proteins are conserved across kingdoms, and their mechanistic understanding holds promise for basic plant biology and agriculture. Here, we discuss the novel enzymatic TIR domain functions of nucleotide-binding leucine-rich repeat receptors (NLRs) in cell death, and posit how TIR domain-containing effectors mechanistically subvert host immune systems.

摘要

含Toll/白细胞介素-1受体（TIR）结构域的蛋白质在不同生物界中保守，对其作用机制的理解有望推动基础植物生物学和农业发展。在此，我们讨论了核苷酸结合富含亮氨酸重复序列受体（NLR）的新型酶促TIR结构域在细胞死亡中的功能，并推测含TIR结构域的效应蛋白如何在机制上颠覆宿主免疫系统。