Alber D, Moussard C, Agnani G, Lorin V, Colette C, Henry J C
Pathol Biol (Paris). 1986 Feb;34(2):101-7.
Peritoneal fluid levels of 6-keto-PGF1 alpha, TxB2, PGE2 and PGF2 alpha were measured in 62 infertile women undergoing coelioscopy. In 10 patients with mild endometriosis, the levels of all prostanoids were significantly enhanced as compared to control group (15 infertile patients without pelvic lesion). In 5 patients with moderate endometriosis, only PGF2 alpha exhibited a significant enhancement. The results confirmed the prostanoid component alteration of peritoneal fluid in infertile women with mild or moderate endometriosis, which however not has been found by all authors. In 6 patients with chronic salpingitis, no difference was found in prostanoid levels as compared to control group. The 26 patients with pelvic adhesions were distributed in 3 groups on the criterion of easy lysed or not adhesions. In group I (not lysed adhesions, 7 patients), no difference was found in prostanoid levels as compared to control group. In group II (mixed adhesions, 13 patients), the levels of all prostanoids, particularly 6-keto-PGF1 alpha, were significantly higher than that found in control group. In group III (easy lysed adhesions, 6 patients), the levels of 6-keto-PGF1 alpha, TxB2 and particularly PGF2 alpha were significantly enhanced as compared to control group. The results of this study suggest that prostanoids are implicated in physiopathology of endometriosis and pelvic adhesions and perhaps in mechanism of the associated infertility.
对62名接受腹腔镜检查的不孕女性的腹腔液中6-酮-前列腺素F1α、血栓素B2、前列腺素E2和前列腺素F2α水平进行了测量。在10例轻度子宫内膜异位症患者中，与对照组（15例无盆腔病变的不孕患者）相比，所有前列腺素的水平均显著升高。在5例中度子宫内膜异位症患者中，仅前列腺素F2α表现出显著升高。结果证实了轻度或中度子宫内膜异位症不孕女性腹腔液中前列腺素成分的改变，然而并非所有作者都发现了这一点。在6例慢性输卵管炎患者中，与对照组相比，前列腺素水平未发现差异。根据粘连是否易于松解的标准，将26例盆腔粘连患者分为3组。在第一组（粘连不易松解，7例患者）中，与对照组相比，前列腺素水平未发现差异。在第二组（混合性粘连，13例患者）中，所有前列腺素的水平，尤其是6-酮-前列腺素F1α，显著高于对照组。在第三组（粘连易于松解，6例患者）中，与对照组相比，6-酮-前列腺素F1α、血栓素B2尤其是前列腺素F2α的水平显著升高。本研究结果表明，前列腺素与子宫内膜异位症和盆腔粘连的病理生理有关，可能也与相关不孕的机制有关。
