乌干达西南部门诊糖尿病护理患者中QTc间期延长的高患病率。

High prevalence of prolonged QTc interval among individuals in ambulatory diabetic care in southwestern Uganda.

作者信息

Migisha Richard, Agaba David Collins, Katamba Godfrey, Miranda Silvia Lopez, Muyingo Anthony, Siedner Mark J

机构信息

Department of Physiology, Mbarara University of Science and Technology, MbararaP.O Box 1410, Uganda.

Department of Physiology, King Ceasor University, Kampala, Uganda.

出版信息

Int J Diabetes Dev Ctries. 2021 Oct;41(4):614-620. doi: 10.1007/s13410-021-00944-6. Epub 2021 Apr 7.

DOI:10.1007/s13410-021-00944-6

PMID:35177883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8849522/

Abstract

BACKGROUND

Heart rate-corrected QT (QTc) interval is associated with increased risk for cardiovascular events and mortality among individuals with diabetes mellitus (DM). Little is known about the epidemiology of prolonged QTc among people with DM in resource-limited settings.

METHODS

We conducted a cross-sectional study among adults with diabetes in ambulatory care at the Mbarara Regional Referral Hospital, from November 2018 to April 2019. Twelve-lead ECG recordings were performed on all participants. We collected clinical and laboratory data related to diabetes disease status and treatment control. We estimated QTc using Bazett's formula and categorized it according to standardized sex-adjusted thresholds. Linear regression analysis was performed to identify correlates of QTc.

RESULTS

We recruited 299 participants with a mean age of 50.1 years (SD±9.8) and mean HbA1c of 9.7 % (SD±2.6), and 69.6% were female. We detected prolonged and borderline QTc in 6.4% (19/299, 95% CI: 3.9-9.7%) and 23.4% (70/299, 95% CI: 18.7-28.6%) of participants, respectively. In multivariate models, factors associated with increasing QTc interval were mean arterial pressure (=0.34; 95% CI: 0.07-0.63, =0.019) and female sex (=15.26; 95% CI: 7.58-22.94, 0.001).

CONCLUSIONS

The prevalence of abnormal QTc among individuals in routine diabetes care in southwestern Uganda was high. Female sex and mean arterial pressure were correlated with QTc interval. Given these findings, future studies should explore the clinical impact of abnormal QTc in this patient population.

摘要

背景

心率校正QT（QTc）间期与糖尿病（DM）患者心血管事件风险增加及死亡率升高相关。在资源有限地区，DM患者QTc延长的流行病学情况鲜为人知。

方法

2018年11月至2019年4月，我们在姆巴拉拉地区转诊医院对门诊成年糖尿病患者进行了一项横断面研究。对所有参与者进行了12导联心电图记录。我们收集了与糖尿病疾病状态和治疗控制相关的临床和实验室数据。我们使用Bazett公式估算QTc，并根据标准化的性别调整阈值对其进行分类。进行线性回归分析以确定QTc的相关因素。

结果

我们招募了299名参与者，平均年龄为50.1岁（标准差±9.8），平均糖化血红蛋白为9.7%（标准差±2.6），69.6%为女性。我们分别在6.4%（19/299，95%置信区间：3.9 - 9.7%）和23.4%（70/299，95%置信区间：18.7 - 28.6%）的参与者中检测到QTc延长和临界延长。在多变量模型中，与QTc间期增加相关的因素是平均动脉压（β = 0.34；95%置信区间：0.07 - 0.63，P = 0.019）和女性性别（β = 15.26；95%置信区间：7.58 - 22.94，P < ）。