UO Geriatria, Hospital of Montefiascone POC, Viterbo, Italy.
Auton Neurosci. 2010 Apr 19;154(1-2):94-8. doi: 10.1016/j.autneu.2009.11.006. Epub 2009 Dec 5.
The QT interval reflects the duration of the intracellular action potential. Little is known on the interval QT duration in non diabetic insulin-resistant subjects.
The aims of the current study were to evaluate the QTc interval in three groups of non diabetic insulin-resistant subjects and the possible correlation between QTc and the autonomic nervous system's activity.
90 subjects were divided in subjects with impaired fasting glycaemia (IFG) and, by the results of OGTT, according to the criteria of ADA, in subjects with normal glucose regulation (NGR) and impaired glucose tolerance (IGT). Insulin resistance was evaluated by the homeostasis model assessment-index (HOMA-I). Heart rate variability and Qtc were calculated.
QTc interval is correlated with SDNN, LF n.u. and LF/HF.
We have observed that the QTc interval is prolonged in insulin-resistant subjects with associated impaired glucose metabolism, while no difference was reported between insulin-resistant and non insulin-resistant subjects with normal glucose regulation. We hypothesize that hyperglycaemia could play a major role than hyperinsulinemia on the QTc prolongation.
QT 间期反映了细胞内动作电位的持续时间。关于非糖尿病胰岛素抵抗患者的 QT 间期持续时间知之甚少。
本研究旨在评估三组非糖尿病胰岛素抵抗患者的 QTc 间期，以及 QTc 与自主神经系统活动之间的可能相关性。
90 名受试者根据 OGTT 结果，按照 ADA 的标准分为空腹血糖受损（IFG）和正常葡萄糖调节（NGR）及糖耐量受损（IGT）组。胰岛素抵抗用稳态模型评估指数（HOMA-I）评估。计算心率变异性和 QTc。
QTc 间期与 SDNN、LF n.u. 和 LF/HF 相关。
我们观察到，伴有葡萄糖代谢受损的胰岛素抵抗患者的 QTc 间期延长，而胰岛素抵抗和葡萄糖调节正常的患者之间则没有差异。我们假设高血糖比高胰岛素血症对 QTc 延长的作用更大。
