Soehnlen Neil Thomas, Erb Eric Donald, Kiskaddon Eric McKee, Green Uthona, Froehle Andrew, Krishnamurthy Anil
Dayton Veterans Affairs Medical Center, Ohio.
Wright State University, Dayton, Ohio.
Fed Pract. 2021 Dec;38(12):598-605. doi: 10.12788/fp.0209. Epub 2021 Dec 12.
Ease of access to opioids in the perioperative period is a risk factor for subsequent opioid misuse. The purpose of this study was to quantify a decrease in opioid consumption following implementation of a new analgesic protocol after total knee arthroplasty (TKA).
A retrospective cohort study was performed analyzing patients who underwent TKA at a US Department of Veterans Affairs medical center. Patients were divided into 2 groups by multimodal analgesic regimen: Analgesia with intraoperative general anesthesia, a patient-controlled analgesia pump, and oral opioids (control group) or analgesia with intraoperative spinal anesthesia, a multimodal medication regimen, and an adductor canal block (protocol group).
A total of 533 TKAs were included. The mean (SD) IV morphine equivalent dose (MED) requirement was 178.2 (98.0) for the control and 12.0 (24.6) for the protocol group ( < .001). Total mean (SD) opioid MED requirement was 241.7 (120.1) for the control group and 74.8 (42.7) for the protocol group ( < .001). The protocol group required only 6.7% of the IV opioids and the control group 30.9%. No difference in oral opioid requirements was found ( = .85). The control group required more opioid refills at the first postoperative visit ( < .001).
The described analgesic protocol resulted in significant decreases in IV and total opioid requirement, and lower rates of opioid prescriptions at the first postoperative visit. These findings demonstrate a decrease in opioid utilization with modern perioperative analgesia protocols and reinforce multiple recommendations to decrease opioid exposure and access.
围手术期容易获得阿片类药物是后续阿片类药物滥用的一个风险因素。本研究的目的是量化全膝关节置换术(TKA)后实施新的镇痛方案后阿片类药物消耗量的减少情况。
进行了一项回顾性队列研究,分析在美国退伍军人事务部医疗中心接受TKA的患者。根据多模式镇痛方案将患者分为两组:术中全身麻醉、患者自控镇痛泵和口服阿片类药物镇痛(对照组)或术中脊髓麻醉、多模式药物方案和内收肌管阻滞镇痛(方案组)。
共纳入533例TKA患者。对照组静脉注射吗啡等效剂量(MED)的平均(标准差)需求量为178.2(98.0),方案组为12.0(24.6)(P<0.001)。对照组阿片类药物MED的总平均(标准差)需求量为241.7(120.1),方案组为74.8(42.7)(P<0.001)。方案组仅需要对照组6.7%的静脉注射阿片类药物,对照组为30.9%。口服阿片类药物需求量未发现差异(P = 0.85)。对照组在术后首次随访时需要更多的阿片类药物补充(P<0.001)。
所描述的镇痛方案导致静脉注射和总阿片类药物需求量显著降低,且术后首次随访时阿片类药物处方率较低。这些发现表明现代围手术期镇痛方案可降低阿片类药物的使用,并强化了多项减少阿片类药物暴露和可及性的建议。