Kaeley Nidhi, Kabi Ankita, Pillai Aadya, Shankar Takshak, Ameena M S Salva
Emergency Medicine, All India Institute of Medical Sciences, Rishikesh, IND.
Emergency Medicine (Anaesthesiology), All India Institute of Medical Sciences, Rishikesh, IND.
Cureus. 2022 Jan 14;14(1):e21246. doi: 10.7759/cureus.21246. eCollection 2022 Jan.
Coronavirus disease 2019 (COVID-19) predominantly affects the respiratory system with manifestations ranging from a mild upper respiratory tract infection to severe acute respiratory distress syndrome. Neurological manifestations of COVID-19 are mainly thrombotic manifestations affecting the nervous system; however, demyelinating manifestation has been less defined. Although some recent studies have described the association between COVID-19 and Guillain-Barré syndrome (GBS), the strength of association and features of GBS in this setting are not yet clear. Here, we report one adult case of COVID-19 infection presenting with acute GBS, which was not preceded by any other respiratory, gastrointestinal, or other systemic infections. We performed a literature search in Medline via PubMed using the keywords or MeSH terms "COVID-19" or "SARS-CoV-2" and "Guillain-Barré syndrome" and "AIDP" and "AMAN," "Miller-Fischer syndrome" or "MFS." We reviewed 99 case reports, 38 reviews, and two meta-analyses. Several published reports have described a possible association between GBS and COVID-19 infection.
2019冠状病毒病（COVID-19）主要影响呼吸系统，表现范围从轻度上呼吸道感染到严重急性呼吸窘迫综合征。COVID-19的神经系统表现主要是影响神经系统的血栓形成表现；然而，脱髓鞘表现尚未明确界定。尽管最近一些研究描述了COVID-19与吉兰-巴雷综合征（GBS）之间的关联，但这种情况下关联的强度和GBS的特征尚不清楚。在此，我们报告1例成人COVID-19感染病例，该病例表现为急性GBS，且在发病前没有任何其他呼吸道、胃肠道或其他全身感染。我们通过PubMed在Medline中进行文献检索，使用关键词或医学主题词“COVID-19”或“SARS-CoV-2”以及“吉兰-巴雷综合征”和“急性炎症性脱髓鞘性多发性神经病”和“急性运动轴索性神经病”、“米勒-费希尔综合征”或“MFS”。我们回顾了99篇病例报告、38篇综述和两项荟萃分析。一些已发表的报告描述了GBS与COVID-19感染之间可能存在的关联。
