Department of Oncology, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Biomed Res Int. 2022 Feb 8;2022:7184871. doi: 10.1155/2022/7184871. eCollection 2022.
Chemotherapy is a common drug for lung cancer. Nevertheless, the development of drug resistance greatly limits their clinical efficacy. Therefore, to reduce drug resistance, we need to constantly explore new treatments. This study is aimed at determining the role of rhein in the proliferation and metastasis of lung cancer cell. Our study found that rhein significantly inhibits the proliferation and migration of lung cancer cells. Additionally, the mRNA expression and protein levels of Snail, MMP2, and MMP9 are decreasing in lung cancer cells treated by rhein. Our results showed that rhein plays a vital role in proliferation and metastasis of chemosensitive and chemoresistant lung cancer cells, and the mechanism may be related to the Stat3/Snail/MMP2/MMP9 pathway.
化疗是一种常见的肺癌药物。然而，耐药性的发展极大地限制了它们的临床疗效。因此，为了降低耐药性，我们需要不断探索新的治疗方法。本研究旨在确定大黄酸在肺癌细胞增殖和转移中的作用。我们的研究发现，大黄酸能显著抑制肺癌细胞的增殖和迁移。此外，大黄酸处理的肺癌细胞中 Snail、MMP2 和 MMP9 的 mRNA 表达和蛋白水平降低。我们的结果表明，大黄酸在化疗敏感和耐药的肺癌细胞的增殖和转移中起着重要作用，其机制可能与 Stat3/Snail/MMP2/MMP9 通路有关。
