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一种可穿戴的全凝胶多模式皮肤传感器,可实现单个部位的心脏相关生物物理信号的同步监测。

A Wearable All-Gel Multimodal Cutaneous Sensor Enabling Simultaneous Single-Site Monitoring of Cardiac-Related Biophysical Signals.

机构信息

Institute of Advanced Machinery Design Technology, Korea University, Anam-Dong, Seongbuk-Gu, Seoul, 136-713, Republic of Korea.

School of Mechanical Engineering, College of Engineering, Korea University, Anam-Dong, Seongbuk-Gu, Seoul, 136-713, Republic of Korea.

出版信息

Adv Mater. 2022 Apr;34(16):e2110082. doi: 10.1002/adma.202110082. Epub 2022 Mar 13.

Abstract

The human cutaneous sensory organ is a highly evolved biosensor that is efficient, sensitive, selective, and adaptable. Recently, with the development of various materials and structures inspired by sensory organs, artificial cutaneous sensors have been widely studied. In this study, the acquisition of biophysical signals is demonstrated at one point on the body using a wearable all-gel-integrated multimodal sensor composed of four element sensors, inspired by the slow/rapid adapting functions of the skin sensory receptors. The gel-type sensors ensure flexibility, compactness, portability, adherence, and integrity. The wearable all-gel multimodal sensor is easily attached to the wrist and simultaneously gathers blood pressure (BP), electrocardiogram (ECG), electromyogram (EMG), and mechanomyogram (MMG) signals related to cardiac and muscle health. Human activity causes muscle contraction, which affects blood flow; therefore, the relationship between the muscle and heart is crucial for screening and predicting heart health. Cardiac health is monitored by obtaining the two types of phase time differences (i.e., Δt : BP and ECG, Δt : ECG and MMG) generated during muscle movement. The suggested multimodal sensor has potential applicability in monitoring biophysical conditions and diagnosing cardiac-related health problems.

摘要

人体皮肤感觉器官是一种高度进化的生物传感器,具有高效、敏感、选择性和适应性。最近,随着各种受感觉器官启发的材料和结构的发展,人工皮肤传感器得到了广泛的研究。在这项研究中,使用由四个元件传感器组成的全凝胶集成多模态传感器,在身体的一个点上演示了生物物理信号的获取,该传感器的灵感来自皮肤感觉受体的慢/快适应功能。凝胶型传感器确保了灵活性、紧凑性、便携性、粘附性和完整性。这种可穿戴的全凝胶多模态传感器可以轻松地贴在手腕上,同时收集与心脏和肌肉健康相关的血压 (BP)、心电图 (ECG)、肌电图 (EMG) 和肌肉运动图 (MMG) 信号。人体活动引起肌肉收缩,从而影响血液流动;因此,肌肉和心脏之间的关系对于筛查和预测心脏健康至关重要。通过获得肌肉运动过程中产生的两种相位时间差 (即 Δt:BP 和 ECG、Δt:ECG 和 MMG) 来监测心脏健康。该建议的多模态传感器在监测生物物理条件和诊断与心脏相关的健康问题方面具有潜在的适用性。

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