Alay Murat, Sonmez Miyase Gulcin, Sakin Aysegul, Atmaca Murat, Suleyman Halis, Yazici Gulce Naz, Coban Abdulkadir, Suleyman Bahadir, Bulut Seval, Altuner Durdu
Department of Endocrinology and Metabolism, Van Yuzuncu Yil University School of Medicine, Turkey.
Department of Internal Medicine, Van Yuzuncu Yil University School of Medicine, Turkey.
Adv Clin Exp Med. 2022 Apr;31(4):427-435. doi: 10.17219/acem/144002.
Hyperglycemia can be considered a determining factor in the development of diabetic neuropathy as well as neuropathic pain. There is a relationship between the excessive production of reactive oxygen species (ROS) and the pathogenesis of diabetic neuropathic pain. Taxifolin, on the other hand, is a flavonoid that has been documented to inhibit ROS production.
To investigate the effects of taxifolin, which has antioxidant and neuroprotective effects, on alloxan-induced hyperglycemia-induced neuropathy and neuropathic pain, biochemically and histopathologically.
The albino Wistar male rats were divided into 3 groups: healthy group (HG), only alloxan group (AXG) and alloxan+taxifolin group (ATG). Hyperglycemia in animals was caused through intraperitoneal injection of alloxan at a dose of 120 mg/kg. Paw pain thresholds of animals were measured using Basile algesimeter. Sciatic nerve tissues were examined biochemically and histopathologically in order to evaluate neuropathy.
Our experimental results revealed that taxifolin significantly prevented the increase of plasma glucose concentration level with alloxan administration, the decrease of the paw pain threshold related to hyperglycemia, the change of oxidant-antioxidant balance in the sciatic nerve tissue in favor of oxidants, and the deterioration of tissue morphology in animals.
Our experimental results indicate that taxifolin alleviates alloxan-induced hyperglycemia-related neuropathy and neuropathic pain.
高血糖可被视为糖尿病性神经病变以及神经性疼痛发展的决定性因素。活性氧（ROS）的过量产生与糖尿病性神经病理性疼痛的发病机制之间存在关联。另一方面，紫杉叶素是一种已被证明可抑制ROS产生的类黄酮。
从生化和组织病理学角度研究具有抗氧化和神经保护作用的紫杉叶素对四氧嘧啶诱导的高血糖相关神经病变和神经性疼痛的影响。
将白化Wistar雄性大鼠分为3组：健康组（HG）、单纯四氧嘧啶组（AXG）和四氧嘧啶+紫杉叶素组（ATG）。通过腹腔注射120mg/kg剂量的四氧嘧啶使动物产生高血糖。使用Basile测痛仪测量动物的爪部疼痛阈值。为评估神经病变，对坐骨神经组织进行生化和组织病理学检查。
我们的实验结果表明，紫杉叶素可显著阻止四氧嘧啶给药后血浆葡萄糖浓度水平的升高、与高血糖相关的爪部疼痛阈值的降低、坐骨神经组织中氧化还原平衡向氧化剂方向的变化以及动物组织形态的恶化。
我们的实验结果表明，紫杉叶素可减轻四氧嘧啶诱导的高血糖相关神经病变和神经性疼痛。
