Wei Xin-Tong, Wang Jie, Chen Wei, Wei Yan-Ping, Lyu Yan-Hui, Zu Xian-Peng, Zhang Xiu-Yun
School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China School of Pharmacy, Naval Medical University Shanghai 200433, China.
School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
Zhongguo Zhong Yao Za Zhi. 2022 Feb;47(3):593-602. doi: 10.19540/j.cnki.cjcmm.20210927.601.
Chinese medicine processing is a procedure to process medicinal materials under the guidance of traditional Chinese medicine(TCM) theories by using unique methods in China. The medicinal materials can only be used clinically after proper processing. With the development of the modernization of TCM, it is difficult to solve the problems in the inheritance, development, and internationalization of Chinese medicine processing. Metabonomics, a new omics technology developed at the end of the last century, is used to infer the physiological or pathological conditions of the organism with the methods such as NMR and LC-MS via investigating the changes in endogenous small molecule metabolic network after the organism is stimulated by external environment. Metabonomics coincides with the holistic view of TCM because it displays the characteristics of integrity, comprehensiveness, and dynamics, and it has been widely applied in the field of Chinese medicine processing in recent years. This study summarized the application of metabonomics in the processing mechanism and quality control of Chinese medicine processing and prospected the development of this technology in the field of Chinese medicine processing.
中药炮制是在中国传统中医理论指导下，运用中国特有的方法对中药材进行加工的过程。中药材只有经过适当炮制后才能用于临床。随着中医现代化的发展，中药炮制在传承、发展和国际化方面存在的问题难以解决。代谢组学是上世纪末发展起来的一种新的组学技术，通过研究生物体受到外界环境刺激后内源性小分子代谢网络的变化，运用核磁共振（NMR）和液相色谱-质谱联用（LC-MS）等方法推断生物体的生理或病理状况。代谢组学与中医的整体观相契合，因为它具有整体性、综合性和动态性的特点，近年来已在中药炮制领域得到广泛应用。本研究综述了代谢组学在中药炮制机理及质量控制方面的应用，并对该技术在中药炮制领域的发展进行了展望。
