Leedy M G, Hart B L
Physiol Behav. 1986;36(3):501-6. doi: 10.1016/0031-9384(86)90322-7.
Bilateral lesions of the medial preoptic-anterior hypothalamic (MP-AH) area were made in prepubertal male cats at 6-8 weeks of age. All subjects were subsequently reared in groups containing male and female peers, until the last phase of the juvenile period when an adult estrous female was inserted in these social groups. In spite of such optimal conditions for the practice of sociosexual behaviors during development, no sparing of adult male copulatory behavior was observed in these MP-AH animals during testing in adulthood. This finding, while consistent with earlier work on dogs, contrasts with the results obtained in prepubertally lesioned rats. Urine spraying, another sexually dimorphic behavior which is eliminated by MP-AH lesions in adult cats, was spared by prepubertal lesion placement. Heterotypical sexual behavior was not enhanced by prepubertal MP-AH lesion placement, as it is with postpubertal placement. In the present study, therefore, different behavioral systems influenced by the MP-AH area showed varying degrees of plasticity. As found in dogs, prepubertal MP-AH lesions enhanced and accelerated testosterone secretion in cats.
在6至8周龄的青春期前雄性猫身上制造了内侧视前 - 下丘脑前部（MP - AH）区域的双侧损伤。随后，所有实验对象都在包含雄性和雌性同伴的群体中饲养，直到幼年期末期，此时将一只成年发情雌性猫放入这些社会群体中。尽管在发育过程中有进行社会性行为的如此理想条件，但在成年期测试期间，这些MP - AH动物中未观察到成年雄性交配行为的保留。这一发现虽然与早期对狗的研究一致，但与青春期前损伤的大鼠所获得的结果形成对比。尿液喷洒是另一种成年猫中MP - AH损伤会消除的性别二态性行为，青春期前损伤部位则使其得以保留。青春期前MP - AH损伤部位并未像青春期后损伤那样增强异型性行为。因此，在本研究中，受MP - AH区域影响的不同行为系统表现出不同程度的可塑性。正如在狗身上发现的那样，青春期前MP - AH损伤增强并加速了猫的睾酮分泌。
