Hart B L, Ladewig J
Neuroendocrinology. 1980;30(1):20-4. doi: 10.1159/000122969.
Lesions of the medial preoptic-anterior hypothalamic (MP-AH) continuum made in juvenile male dogs (10-11 weeks of age) were previously reported to reduce juvenile mounting and virtually eliminate male copulatory behavior in adulthood. The effects of these lesions on the developmental patterns of serum testosterone (T) and luteinizing hormone (LH) were examined in the present study. Subjects with MP-AH lesions (MP-AH subjects) had a pubertal rise in serum T almost 2 months before subjects with sham lesions (SHAM subjects). Subsequently mean serum T of MP-AH subjects rose to levels significantly higher than those of SHAM subjects before falling back to the normal 3-4 ng/ml range of SHAM subjects at 10 months. There was no apparent relationship between secretion of LH and the acceleration and enhancement of serum T. These observations indicate that there can be impairment of male sexual behavior with lesions that accelerate and enhance sexual functioning in other respects.
先前有报道称，对幼年雄性犬（10 - 11周龄）的内侧视前 - 下丘脑前部（MP - AH）连续区域进行损伤，会减少幼年时的爬跨行为，并几乎消除成年后的雄性交配行为。在本研究中，检测了这些损伤对血清睾酮（T）和促黄体生成素（LH）发育模式的影响。与假手术损伤组（SHAM组）相比，MP - AH损伤组（MP - AH组）的血清T在青春期上升的时间提前了近2个月。随后，MP - AH组的血清T均值上升到显著高于SHAM组的水平，之后在10个月时回落至SHAM组正常的3 - 4 ng/ml范围。LH的分泌与血清T的加速和升高之间没有明显关系。这些观察结果表明，在其他方面加速和增强性功能的损伤可能会损害雄性性行为。
