Rowland N E, Miceli M O, Malsbury C W, Baile C A, Della-Fera M A, Gingerich R L, Caputo F A
Physiol Behav. 1986;36(3):513-21. doi: 10.1016/0031-9384(86)90324-0.
Syrian golden hamsters (Mesocricetus auratus) received bilateral lesions aimed at the ventromedial hypothalamus (VMH) or a sham lesion. In the first study, some of the animals in each surgical group were housed in standard sedentary conditions while others had free access to running wheels. The lesions produced a 30% increase in the daily intake of chow, and this was accomplished exclusively by increased meal sizes. As a result, lesioned hamsters gained body weight relative to controls both on the chow diet and in a subsequent high fat diet phase. The effects were comparable in both sedentary and exercising groups. The lesions produced increases in body length and fat content. In the second study, lesions were made in the VMH or in adjacent nuclei and, after an initial period on chow, the hamsters were then given a choice between chow and high fat diet. The lesioned hamsters showed no unusual preference for the high fat diet but, as before, those with damage to the VMH or paraventricular nucleus (PVN) showed exaggerated body weight gain. Hamsters with these lesions were hyperinsulinemic in both fed and fasted conditions at the end of the study.
叙利亚金黄地鼠（Mesocricetus auratus）接受了针对腹内侧下丘脑（VMH）的双侧损伤或假损伤。在第一项研究中，每个手术组的一些动物被饲养在标准的久坐条件下，而其他动物可以自由使用跑步机。损伤导致每日食物摄入量增加30%，这完全是通过增加每餐食量实现的。结果，与对照组相比，损伤的地鼠在食用普通饲料和随后的高脂饮食阶段体重都增加了。久坐组和运动组的效果相当。损伤导致体长和脂肪含量增加。在第二项研究中，在VMH或相邻核团制造损伤，在最初食用普通饲料一段时间后，然后让地鼠在普通饲料和高脂饮食之间进行选择。损伤的地鼠对高脂饮食没有异常偏好，但和之前一样，那些VMH或室旁核（PVN）受损的地鼠体重增加更为明显。在研究结束时，有这些损伤的地鼠在进食和禁食状态下均出现高胰岛素血症。
