Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Division of Urology, Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
J Urol. 2022 Apr;207(4):814-822. doi: 10.1097/JU.0000000000002334. Epub 2022 Feb 17.
We examined the effects of exercise on prostate cancer-specific anxiety, fear of cancer progression, quality of life and psychosocial outcomes in patients with prostate cancer on active surveillance.
The ERASE (Exercise during Active Surveillance for Prostate Cancer) Trial randomized 52 patients with prostate cancer undergoing active surveillance to high-intensity interval training (HIIT, 26 patients) or usual care (UC, 26 patients). The HIIT group performed a 12-week, thrice weekly, supervised, aerobic HIIT program. The UC group did not exercise. Patient-reported outcomes were assessed at baseline and after intervention, including prostate cancer-specific anxiety (Memorial Anxiety Scale for Prostate Cancer), fear of cancer progression (Fear of Cancer Recurrence Inventory), prostate cancer symptoms (Expanded Prostate Cancer Index Composite), quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core) and psychological health outcomes (eg fatigue, stress and self-esteem). Analysis of covariance was used to compare between-group differences.
Fifty of 52 participants (96%) completed patient-reported outcome assessments at 12 weeks. Adherence to HIIT was 96%. Compared to UC, HIIT significantly improved total prostate cancer-specific anxiety (adjusted between-group mean difference -2.7, 95% confidence interval, range -5.0 to -0.4, p=0.024), as well as the fear of progression subscale (p=0.013), hormonal symptoms (p=0.005), perceived stress (p=0.037), fatigue (p=0.029) and self-esteem (p=0.007).
A 12-week supervised HIIT program may improve prostate cancer-specific anxiety, fear of cancer progression, hormone symptoms, stress, fatigue and self-esteem in men with prostate cancer on active surveillance. Larger trials are needed to confirm the effects of HIIT on patient-reported outcomes in the active surveillance setting.
我们研究了运动对接受主动监测的前列腺癌患者的前列腺癌特异性焦虑、癌症进展恐惧、生活质量和心理社会结局的影响。
ERASE（前列腺癌主动监测期间的运动）试验将 52 名接受主动监测的前列腺癌患者随机分为高强度间歇训练（HIIT，26 名患者）或常规护理（UC，26 名患者）组。HIIT 组进行了 12 周、每周 3 次、监督的有氧运动 HIIT 计划。UC 组不运动。在基线和干预后评估患者报告的结果，包括前列腺癌特异性焦虑（前列腺癌特异性焦虑量表）、对癌症进展的恐惧（癌症复发恐惧量表）、前列腺癌症状（前列腺癌指数综合量表）、生活质量（欧洲癌症研究与治疗组织生活质量问卷核心量表）和心理健康结果（例如疲劳、压力和自尊）。采用协方差分析比较组间差异。
52 名参与者中有 50 名（96%）在 12 周时完成了患者报告的结果评估。HIIT 的依从性为 96%。与 UC 相比，HIIT 显著改善了总前列腺癌特异性焦虑（调整后的组间平均差异-2.7，95%置信区间，范围-5.0 至-0.4，p=0.024），以及对进展的恐惧亚量表（p=0.013）、激素症状（p=0.005）、感知压力（p=0.037）、疲劳（p=0.029）和自尊（p=0.007）。
为期 12 周的监督 HIIT 计划可能会改善接受主动监测的前列腺癌患者的前列腺癌特异性焦虑、癌症进展恐惧、激素症状、压力、疲劳和自尊。需要更大规模的试验来确认 HIIT 在主动监测环境中对患者报告结果的影响。
