Kang Dong-Woo, Field Catherine J, Patel Dhruvesh, Fairey Adrian S, Boulé Normand G, Dieli-Conwright Christina M, Courneya Kerry S
Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton, AB, Canada.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Prostate Cancer Prostatic Dis. 2024 Jul 15. doi: 10.1038/s41391-024-00867-3.
To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate cancer on active surveillance (AS) from the Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial.
Fifty-two men with prostate cancer on AS were randomized to either an exercise (HIIT; n = 26) or usual care (UC; n = 26) group. The HIIT intervention consisted of progressive, supervised, aerobic HIIT at an intensity of 85 to 95% VO for 28 to 40 min per session performed three times/week for 12 weeks. Blood samples were collected at baseline and postintervention to analyze cardiometabolic biomarkers. Analysis of covariance was used to examine between-group mean differences.
Blood data were obtained from 49/52 (94%) participants at postintervention. Participants were aged 63.4 ± 7.1 years and 40% were obese. The HIIT group attended 96% of the planned exercise sessions. No significant between-group changes in weight were observed after the intervention. Compared to UC, HIIT significantly improved total cholesterol (-0.40 mmol/L; 95% confidence interval[CI], -0.70 to -0.10; p = 0.011), non-high-density lipoprotein-c (-0.35 mmol/L; 95% CI, -0.60 to -0.11; p = 0.006), insulin (-13.6 pmol/L; 95% CI, -25.3 to -1.8; p = 0.025), insulin-like growth factor (IGF)-1 (-15.0 ng/mL; 95% CI, -29.9 to -0.1; p = 0.048), and IGF binding protein (IGFBP)-3 (152.3 ng/mL; 95% CI, 12.6 to 292.1; p = 0.033). No significant differences were observed for fasting glucose, HbA1c, other lipid markers, IGFBP-1, adiponectin, and leptin.
The ERASE Trial showed that a 12-week aerobic HIIT program improved several cardiometabolic biomarkers in patients with prostate cancer on AS that may contribute to cardiovascular health benefits and potentially influence signaling pathways in the progression of prostate cancer. Further research is needed to confirm the effects of exercise on cardiometabolic markers in men with prostate cancer on AS and determine if these effects are associated with improved long-term clinical outcomes.
报告一项为期12周的高强度间歇训练（HIIT）计划对前列腺癌积极监测（AS）患者心脏代谢生物标志物的影响，该研究来自前列腺癌积极监测期间运动（ERASE）试验。
52名接受AS的前列腺癌男性被随机分为运动组（HIIT；n = 26）或常规护理组（UC；n = 26）。HIIT干预包括渐进式、有监督的有氧HIIT，强度为85%至95%VO，每次训练28至40分钟，每周进行3次，共12周。在基线和干预后采集血样以分析心脏代谢生物标志物。采用协方差分析来检验组间平均差异。
干预后从49/52（94%）名参与者中获得了血液数据。参与者年龄为63.4±7.1岁，40%为肥胖者。HIIT组参加了96%的计划训练课程。干预后未观察到组间体重有显著变化。与UC组相比，HIIT显著改善了总胆固醇（-0.40 mmol/L；95%置信区间[CI]，-0.70至-0.10；p = 0.011）、非高密度脂蛋白-c（-0.35 mmol/L；95% CI，-0.60至-0.11；p = 0.006）、胰岛素（-13.6 pmol/L；95% CI，-25.3至-1.8；p = 0.025）、胰岛素样生长因子（IGF）-1（-15.0 ng/mL；95% CI，-29.9至-0.1；p = 0.048）和IGF结合蛋白（IGFBP）-3（152.3 ng/mL；95% CI，12.6至292.1；p = 0.033）。空腹血糖、糖化血红蛋白、其他血脂标志物、IGFBP-1、脂联素和瘦素未观察到显著差异。
ERASE试验表明，一项为期12周的有氧HIIT计划改善了接受AS的前列腺癌患者的几种心脏代谢生物标志物，这可能有助于心血管健康益处，并可能影响前列腺癌进展中的信号通路。需要进一步研究来证实运动对接受AS的前列腺癌男性心脏代谢标志物的影响，并确定这些影响是否与改善长期临床结局相关。
