Waterfield J D, Bick P H, Möller E, Möller G
Scand J Immunol. 1978;7(5):435-8. doi: 10.1111/j.1365-3083.1978.tb00475.x.
Neonatally induced fully tolerant mice possess cytotoxic effector cells, specific for the tolerizing antigens, which can be induced by polyclonal T cell activators in vivo (Con A) on in vitro (poly A:U). Therefore, clonal deletion of specific effector cells is eliminated as the mechanism by which skin grafts are retained in tolerized mice.
新生期诱导产生的完全耐受小鼠拥有对耐受抗原具有特异性的细胞毒性效应细胞，这些细胞可在体内由多克隆T细胞激活剂（刀豆蛋白A）或在体外由（聚肌苷酸:聚胞苷酸）诱导产生。因此，特异性效应细胞的克隆清除作为皮肤移植物在耐受小鼠体内得以保留的机制被排除。
