Reinhold H S, Visser A G
Radiother Oncol. 1986 Mar;5(3):259-64. doi: 10.1016/s0167-8140(86)80055-x.
Multifractionation was about half a century ago used in radiation therapy. This becomes clear from a review of the literature. One case, reported to have been treated by Coutard with multifractionation is discussed in detail. In order to compare the various treatment modalities the authors have plotted the Extrapolated Tolerance Dose (ETD) against the alpha/beta dose (parameters featuring in the linear-quadratic model, L-Q model), and derived the idea of a "tolerance profile". The case treated by Coutard remains closely within the limits of the present day tolerance profile. It remains unclear why multifractionation has disappeared as a treatment modality for 50 years before returning recently.
多分割放疗大约在半个世纪前就已应用于放射治疗。从文献综述中可以清楚地看出这一点。本文详细讨论了一例据报道由库塔德采用多分割放疗治疗的病例。为了比较各种治疗方式，作者绘制了外推耐受剂量（ETD）与α/β剂量（线性二次模型，L-Q模型中的参数）的关系图，并得出了“耐受曲线”的概念。库塔德治疗的该病例仍严格处于当今耐受曲线的范围内。目前尚不清楚为何多分割放疗在最近重新出现之前，作为一种治疗方式消失了50年。
