Willers H, Beck-Bornholdt H P
Institut für Biophysik und Strahlenbiologie, Universität Hamburg.
Strahlenther Onkol. 1996 Sep;172(9):512-5.
BACKGROUND/MATERIAL: Today as well as in the first decades of this century the time factor has been one central subject of radio-oncological research. Before World War II, all possible overall treatment times ranging from 1 day to several months were under clinical investigation. A major portion of these historical irradiation schemes is documented in the German written literature of this time period, particularly in the journal "Strahlentherapie".
In Paris, Coutard continuously extended treatment duration in X-ray therapy of malignant head and neck tumors. As illustrated by a reevaluation of these treatment results, with his work Coutard has laid the first foundation for today's international widely used conventional overall treatment times of 6 to 7 weeks. Other authors in the 1920s and 1930s, like Zuppinger or Holthusen, preferred use of slightly shorter overall times.
In retrospect, evidence from these historical evaluations must be regarded as very limited especially from a statistical standpoint of view. Without knowledge of the underlying raw data, particularly the results and conclusions of Coutard which had major impact on the later development of radiation therapy cannot be verified anymore. This indicates the value of publishing raw data in modern radio-oncology as well.
背景/材料：在当今以及本世纪的头几十年里，时间因素一直是放射肿瘤学研究的一个核心主题。第二次世界大战之前，所有可能的总治疗时间，从1天到几个月，都在临床研究之中。这些历史照射方案的一大部分记录在这个时期的德语书面文献中，特别是在《放射治疗学》杂志上。
在巴黎，库塔德不断延长恶性头颈部肿瘤X线治疗的持续时间。通过对这些治疗结果的重新评估表明，库塔德的工作为当今国际上广泛使用的6至7周的传统总治疗时间奠定了首个基础。20世纪20年代和30年代的其他作者，如祖平格或霍尔图森，则倾向于使用稍短的总治疗时间。
回顾过去，这些历史评估的证据，特别是从统计学角度来看，必须被视为非常有限。如果不了解基础原始数据，特别是对放射治疗后期发展有重大影响的库塔德的结果和结论就无法再得到验证。这也表明了在现代放射肿瘤学中公布原始数据的值。
