Department of Orthopaedics, UT Health San Antonio, San Antonio, Texas.
Department of Orthopaedics, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts.
JBJS Rev. 2022 Feb 21;10(2):01874474-202202000-00011. doi: e21.00184.
»: Marijuana use is on the rise in the United States, and there is a paucity of information on the effects of cannabis and its chemical constituents on bone health, wound-healing, surgical complications, and pain management.
»: Current evidence suggests that cannabidiol (CBD) may enhance bone health and metabolism, while Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive component in marijuana, has an inhibitory effect.
»: Marijuana users are at higher risk for delayed bone-healing, demonstrate lower bone mineral density, are at increased risk for fracture, and may experience postoperative complications such as increased opioid use and hyperemesis.
在美国，大麻的使用呈上升趋势，而关于大麻及其化学成分对骨骼健康、伤口愈合、手术并发症和疼痛管理的影响的信息却很少。
目前的证据表明，大麻二酚（CBD）可能会增强骨骼健康和新陈代谢，而大麻中的主要精神活性成分Δ9-四氢大麻酚（Δ9-THC）则具有抑制作用。
大麻使用者的骨愈合延迟风险更高，骨密度更低，骨折风险增加，并且可能会经历术后并发症，例如增加阿片类药物的使用和恶心。
