Hartman Budnik Jasmine V, Higgins Thomas F, Malfait Anne-Marie, Weinrich Jarret A P, Basbaum Allan I, Hsu Joseph R, Morshed Saam, Bahney Chelsea S
Steadman Philippon Research Institute, Vail, CO.
University of Utah, Salt Lake City, UT.
OTA Int. 2025 Apr 1;8(2 Suppl):e352. doi: 10.1097/OI9.0000000000000352. eCollection 2025 Apr.
Traumatic injuries are associated with significant acute pain and subsequent high risk of the development of chronic pain. However, addressing pain after skeletal trauma presents a complex challenge to achieve effective pain relief that minimizes risk of addiction and does not interfere with functional recovery. The Orthopaedic Trauma Association's 2023 Basic Science Focus Forum aimed to bridge the gap between basic science and clinical outcomes with an educational symposium on pain management designed to foster collaboration and provide practical strategies from the frontiers of pain research. Owing to the subjective and multifaceted nature of pain, the development of effective preclinical and clinical pain assessment measures is the first step to making impactful progress in studying pain. Preclinical models prove a valuable tool for studying the molecular mechanisms associated with pain following orthopaedic trauma. These models also allow study of the efficacy of novel pain management techniques, such as testing novel analgesics. Translating novel analgesics and pain management strategies to the clinic requires that we have accurate methods to describe pain to determine whether new approaches are meaningful. It is also necessary to recognize the patient's role and the importance of patient education in the prevention of pain medication misuse, particularly in light of the current national opioid crisis. Overall, collaboration with orthopaedic surgeons in the application of these strategies in a clinical setting is vital for addressing the downfalls of current pain management efforts and providing patients with safe and effective improvements in pain relief after skeletal trauma.
创伤性损伤会导致严重的急性疼痛，并随后产生慢性疼痛的高风险。然而，处理骨骼创伤后的疼痛是一项复杂的挑战，要实现有效的疼痛缓解，同时将成瘾风险降至最低且不干扰功能恢复。骨科创伤协会2023年基础科学聚焦论坛旨在通过一场关于疼痛管理的教育研讨会弥合基础科学与临床结果之间的差距，该研讨会旨在促进合作，并提供来自疼痛研究前沿的实用策略。由于疼痛具有主观性和多面性，开发有效的临床前和临床疼痛评估措施是在疼痛研究中取得重大进展的第一步。临床前模型是研究骨科创伤后与疼痛相关分子机制的宝贵工具。这些模型还允许研究新型疼痛管理技术的疗效，例如测试新型镇痛药。将新型镇痛药和疼痛管理策略转化到临床需要我们有准确的方法来描述疼痛，以确定新方法是否有意义。认识到患者的作用以及患者教育在预防止痛药滥用方面的重要性也很有必要，特别是鉴于当前全国性的阿片类药物危机。总体而言，在临床环境中与骨科医生合作应用这些策略对于解决当前疼痛管理工作的不足，并为骨骼创伤后的患者提供安全有效的疼痛缓解改善至关重要。
