Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Cancer Res. 2022 Feb 15;82(4):537-538. doi: 10.1158/0008-5472.CAN-21-4159.
The tumor microenvironment (TME) shows heterogeneity within a tumor. An important element of the TME is cancer-associated fibroblasts (CAF). In this issue of Cancer Research, Bouchard and colleagues investigate the heterogeneity of CAFs from spatially different zones of lung adenocarcinoma resection specimens. Multiomics analysis revealed changes in the O-glycoproteome, unique to CAFs from the tumor edge, an effect reinforced by contact with cancer cells. This O-glycoprotein signature offers unique targeting perspectives that reciprocally affect cancer cell epithelial-to-mesenchymal plasticity, a key mechanism of cancer progression. Deeper understanding of the cancer-stimulating and cancer-inhibiting role of CAF subtypes will facilitate the development of CAF-directed therapeutic approaches. See related article by Bouchard et al., p. 648.
肿瘤微环境（TME）在肿瘤内表现出异质性。TME 的一个重要组成部分是癌相关成纤维细胞（CAF）。在本期《Cancer Research》中，Bouchard 及其同事研究了肺腺癌切除标本空间上不同区域的 CAF 的异质性。多组学分析显示，来自肿瘤边缘的 CAF 中 O-糖蛋白组发生变化，这种变化受到与癌细胞接触的加强。这种 O-糖蛋白特征提供了独特的靶向视角，反过来又影响癌细胞上皮-间充质转化的可塑性，这是癌症进展的关键机制。更深入地了解 CAF 亚型的促进癌症和抑制癌症的作用将有助于开发针对 CAF 的治疗方法。请参阅 Bouchard 等人的相关文章，第 648 页。
