时间很重要：人类类囊胚类似于囊胚发育的顺序。

Time matters: Human blastoids resemble the sequence of blastocyst development.

机构信息

Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

Altos Labs, 5510 Morehouse Dr., Ste. 300, San Diego, CA 92121, USA.

出版信息

Cell. 2022 Feb 17;185(4):581-584. doi: 10.1016/j.cell.2022.01.005.

DOI:10.1016/j.cell.2022.01.005

PMID:35180387

Abstract

In a recent issue of Nature, Kagawa et al. reported a highly efficient and robust protocol for generating human blastoids from naive human pluripotent stem cells. The blastoids resemble human blastocysts, follow the sequential lineage specification of blastocyst development, and can attach to endometrial cells with the polar trophectoderm to model implantation.

摘要

在最近一期的《自然》杂志上，Kagawa 等人报道了一种从原始人类多能干细胞中生成人类类胚体的高效、稳健的方案。这些类胚体类似于人类囊胚，遵循囊胚发育的顺序谱系特化，并能与具有极性滋养外胚层的子宫内膜细胞附着，以模拟着床。