Rosner Margit, Horer Stefanie, Kiss Izabella, Hengstschläger Markus
Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Währinger Straße 10, 1090, Vienna, Austria.
Stem Cell Res Ther. 2025 Aug 29;16(1):471. doi: 10.1186/s13287-025-04581-2.
Recently, the research field revolving around the stem cell-based modeling of the human embryo gained particular momentum when the first integrated models were designed with the aim to recapitulate the development of the entire early human conceptus. The underlying driving force to reconstruct embryo-like structures is the prospect of a more comprehensive understanding of the fundamental processes controlling early human embryogenesis including their deregulation causing reproductive failures, and the endeavor to use these embryo models for drug testing and disease modeling. Although efforts will continue to create improved models with steadily increasing fidelity to human embryogenesis, the next phase focusing on the application of human embryo models as a platform to address particular scientific questions is currently being entered. In this review, we discuss the benefits, promises and limitations associated with the use of non-integrated and integrated stem cell-based human embryo models in translational research and biomedical applications.
最近，当首个旨在概括整个人类早期胚胎发育的整合模型被设计出来时，围绕基于干细胞的人类胚胎建模的研究领域获得了特别的发展动力。重建类胚胎结构的潜在驱动力是更全面理解控制人类早期胚胎发育的基本过程（包括导致生殖失败的失调过程）的前景，以及将这些胚胎模型用于药物测试和疾病建模的努力。尽管人们将继续努力创建对人类胚胎发育逼真度不断提高的改进模型，但目前正进入下一阶段，即专注于将人类胚胎模型用作解决特定科学问题的平台。在这篇综述中，我们讨论了在转化研究和生物医学应用中使用非整合型和整合型基于干细胞的人类胚胎模型的益处、前景和局限性。
