Deakin University, Faculty of Health, Institute for Health Transformation, Geelong, Australia.
Mental Health Program, QIMR Medical Research Institute, Brisbane, Australia; Metro North Mental Health Service, Herston, Brisbane, Australia.
Schizophr Res. 2022 Mar;241:251-259. doi: 10.1016/j.schres.2022.01.051. Epub 2022 Feb 15.
To identify and describe the available literature quantifying the economic burden associated with the negative symptoms of schizophrenia.
A search of five electronic databases (Medline, PsycINFO, EconLit, CINAHL, EMBASE) and hand searches of bibliographies was conducted to identify all relevant articles written in English and published from date of database inception to January 2021. Search strategies included terms for schizophrenia, negative symptoms, direct and indirect costs and health-care resource utilisation. Quality assessment of included articles was undertaken using a standardised checklist for the evaluation of cost of illness studies. Annual costs were converted to 2022 Australian dollars (A$).
Four hundred and thirty-six abstracts were identified for inclusion. Following screening, six unique studies utilizing data from 6293 participants with an average age of 40 were identified to inform the review. Study quality was high for four studies. All studies concluded there was a positive relationship between negative symptoms and costs or resource utilisation. Four studies providing cost data show an increase in direct costs per annum associated with negative symptoms (range A$ 4046 to 171,564). The wide range in costs was attributable to between study differences in patient characteristics and cohorts, included costs, and country of study.
Health care costs and resource utilisation are associated with negative symptoms in people with schizophrenia. Heterogeneity prevented calculation of an overall dollar value per point increase in negative symptoms. Future research is warranted to further quantify the relationship between negative symptoms and costs, including health sector and societal.
识别和描述现有文献，量化与精神分裂症阴性症状相关的经济负担。
对五个电子数据库（Medline、PsycINFO、EconLit、CINAHL、EMBASE）进行检索，并对参考文献进行手工检索，以确定从数据库创建日期到 2021 年 1 月发表的所有相关英文文献。检索策略包括用于精神分裂症、阴性症状、直接和间接成本以及医疗资源利用的术语。使用成本疾病研究评估的标准化清单对纳入的文章进行质量评估。年度成本转换为 2022 年澳元（A$）。
共确定了 436 篇摘要供纳入。经过筛选，确定了六篇利用来自 6293 名平均年龄为 40 岁的参与者的数据的独特研究来为综述提供信息。四项研究的质量较高。所有研究都得出结论，阴性症状与成本或资源利用之间存在正相关关系。四项提供成本数据的研究表明，与阴性症状相关的直接年度成本增加（范围为 A$4046 至 171564）。成本差异很大，原因是研究之间患者特征和队列、包括的成本以及研究所在国家存在差异。
精神分裂症患者的医疗保健成本和资源利用与阴性症状有关。异质性使得无法计算阴性症状每增加一点的总成本。需要进一步研究来量化阴性症状与成本之间的关系，包括卫生部门和整个社会的成本。
