Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Adv Anat Pathol. 2022 May 1;29(3):154-167. doi: 10.1097/PAP.0000000000000334.
Ovarian serous tumors and related lesions are one of the most common conditions of the female genital tract. While ovarian high-grade serous carcinoma carries high mortality and adverse prognosis, most other serous lesions have better clinical behavior. In recent years, significant progress has been made in understanding the nature and histogenesis of these lesions that has contributed to better and more precise clinical management. Most of the high-grade serous carcinomas involve the ovaries and/or peritoneum, although in most cases, their origin seems to be in the fallopian tube. This view is supported by the recognition of precursor lesions in the fallopian tube, such as p53 signature and serous tubular in situ carcinoma. This paper presents salient morphologic, immunohistochemical, and molecular data related to serous tumors and related lesions of the female pelvis and discusses the histogenetic interrelationship among these lesions in light of current knowledge.
卵巢浆液性肿瘤及相关病变是女性生殖道最常见的疾病之一。卵巢高级别浆液性癌死亡率高，预后不良，而大多数其他浆液性病变具有较好的临床行为。近年来，人们对这些病变的性质和组织发生有了更深入的了解，这有助于更好、更精确地进行临床管理。大多数高级别浆液性癌累及卵巢和/或腹膜，尽管在大多数情况下，其起源似乎在输卵管。这一观点得到了在输卵管中发现的前驱病变的支持，如 p53 标志物和浆液性输卵管原位癌。本文介绍了与女性盆腔浆液性肿瘤及相关病变有关的显著形态学、免疫组织化学和分子数据，并根据目前的知识讨论了这些病变之间的组织发生关系。
