Division of Systems Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.
Vitam Horm. 2022;118:315-336. doi: 10.1016/bs.vh.2021.12.002. Epub 2022 Jan 27.
Increasing evidence indicates that the metabolic hormone, leptin markedly influences the functioning of the hippocampus. In particular, exposure to leptin results in persistent changes in synaptic efficacy at both temporoammonic (TA) and Schaffer Collateral (SC) inputs to hippocampal CA1 neurons. The ability of leptin to regulate TA-CA1 and SC-CA1 synapses has important functional implications, as both synaptic connections play important roles in hippocampal-dependent learning and memory. Here we review the modulatory actions of the hormone leptin at these hippocampal CA1 synapses and explore the impact on learning and memory processes.
越来越多的证据表明，代谢激素瘦素显著影响海马体的功能。特别是，瘦素的暴露会导致海马 CA1 神经元的 temporoammonic（TA）和 Schaffer collateral（SC）输入的突触效能持续变化。瘦素调节 TA-CA1 和 SC-CA1 突触的能力具有重要的功能意义，因为这两种突触连接在海马体依赖的学习和记忆中都起着重要作用。在这里，我们回顾了激素瘦素在这些海马 CA1 突触中的调节作用，并探讨了它对学习和记忆过程的影响。
