Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, Mass.
Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
J Allergy Clin Immunol Pract. 2022 May;10(5):1131-1138. doi: 10.1016/j.jaip.2022.02.007. Epub 2022 Feb 15.
Hypereosinophilic syndrome (HES) is a diverse group of disorders characterized by peripheral blood eosinophilia of 1.5 × 10/L (1,500/μL) or greater with evidence of end-organ damage attributable to eosinophilia and no other cause of the end-organ damage. The HES is rare, especially in children. This review aims to provide best practices in diagnosis and treatment of HES in children, including how to differentiate between primary and secondary causes of hypereosinophilia; how to distinguish the differences in clinical presentation, treatment, and prognosis of HES in children and adults; and how to identify key steps in the evaluation and management of HES in children.
嗜酸性粒细胞增多综合征（HES）是一组不同的疾病，其特征是外周血嗜酸性粒细胞计数为 1.5×10/L（1,500/μL）或更高，伴有可归因于嗜酸性粒细胞增多的终末器官损伤的证据，且无其他终末器官损伤的原因。HES 较为罕见，尤其是在儿童中。本综述旨在为儿童 HES 的诊断和治疗提供最佳实践，包括如何区分嗜酸性粒细胞增多的原发性和继发性原因；如何区分儿童和成人 HES 的临床表现、治疗和预后的差异；以及如何确定儿童 HES 评估和管理中的关键步骤。
