Zou Man, Liu Geyan, Li Yanhui
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2022 Sep 19;13:1018394. doi: 10.3389/fphar.2022.1018394. eCollection 2022.
Idiopathic hypereosinophilic syndrome (IHES) is a rare but life-threatening disease related to a group of myeloproliferative disorders characterized by prolonged eosinophilia of unknown cause and inflammatory damage to multiple organs. Here, we present a 44-year-old female patient complaining of shortness of breath and palpitations for 1 month. Her history and presentation were unremarkable, except for a 3-years history of rheumatoid arthritis treated with ibuprofen (0.3 g per day). Initial examination showed heart rate (HR) 120 bpm, respiratory rate (RR) 20 bpm, temperature (T) 36°C, blood pressure (BP) 130/70 mmHg, ventricular gallop rhythm, rales at the lung bases, soft abdomen, nonpalpable liver and spleen, and slight edema in both lower extremities. Bone marrow aspirate and biopsy confirmed the diagnosis of IHES, while cardiac MRI showed intracardiac thrombus. The symptoms of shortness of breath and palpitation disappeared, the eosinophil counts in routine blood tests were normal, and the thrombus in the cardiac cavity gradually disappeared after combined therapy of anti-hypereosinophilic, anti-coagulant and anti-heart failure treatments.
特发性嗜酸性粒细胞增多综合征（IHES）是一种罕见但危及生命的疾病，与一组骨髓增殖性疾病相关，其特征为原因不明的嗜酸性粒细胞增多持续存在以及多器官的炎性损伤。在此，我们报告一名44岁女性患者，主诉气短和心悸1个月。除了有3年类风湿关节炎病史且一直服用布洛芬（每日0.3 g）外，她的病史和临床表现并无明显异常。初始检查显示心率（HR）120次/分，呼吸频率（RR）20次/分，体温（T）36℃，血压（BP）130/70 mmHg，室性奔马律，肺底部啰音，腹部柔软，肝脏和脾脏未触及，双下肢轻度水肿。骨髓穿刺和活检确诊为IHES，而心脏磁共振成像显示心腔内血栓。在接受抗嗜酸性粒细胞增多、抗凝和抗心力衰竭联合治疗后，气短和心悸症状消失，血常规检查中的嗜酸性粒细胞计数恢复正常，心腔内血栓也逐渐消失。
