Ghanayem B I, Maronpot R R, Matthews H B
Toxicol Appl Pharmacol. 1986 May;83(3):576-83. doi: 10.1016/0041-008x(86)90240-1.
Rats receiving 14 daily gavage doses of 100 or 200 mg/kg ethyl acrylate (EtAc) and killed at varying times following the end of dosing exhibited dose-dependent lesions and recovery from lesions in the forestomach. The glandular stomach which was previously shown to be affected by acute exposure to EtAc appeared to have adapted to resist EtAc toxicity with repeat exposure and appeared normal in all animals. Adaptation of the forestomach was characterized by increased papillomatous thickening with dose. Lesions observed in acute exposure to EtAc were still present with repeat dosing and were more pronounced at the high dose. Forestomachs of rats which received 100 mg/kg EtAc for 14 days were recovered to normal within 2 weeks following the last dose. Forestomachs of rats receiving 200 mg/kg EtAc still exhibited numerous lesions 2 weeks following the last dose, and mucosal hyperplasia was present in the forestomachs at 4 weeks postexposure. Two lesions, submucosal fibrosis and foreign body reaction, became more prevalent in high-dose animals with time. Foreign body reaction, which was present in all animals 4 weeks postexposure, appeared to have resulted from entrapment of hair and/or feed particles in forestomach lesions in the course of healing. It is speculated that the increased cell proliferation and the induced foreign body reactions may contribute to the previously demonstrated carcinogenic effect of EtAc on the rat forestomach.
接受14天每日一次、剂量为100或200毫克/千克丙烯酸乙酯（EtAc）灌胃的大鼠，在给药结束后的不同时间处死，其前胃出现了剂量依赖性损伤以及损伤的恢复情况。先前已表明腺胃会受到急性EtAc暴露的影响，但在重复暴露后似乎已适应以抵抗EtAc毒性，且在所有动物中看起来均正常。前胃的适应性表现为乳头状增厚随剂量增加。重复给药时，急性EtAc暴露中观察到的损伤仍然存在，且在高剂量时更为明显。接受100毫克/千克EtAc灌胃14天的大鼠前胃，在末次给药后2周内恢复正常。接受200毫克/千克EtAc的大鼠前胃，在末次给药后2周仍表现出大量损伤，且在暴露后4周时前胃出现黏膜增生。随着时间推移，两种损伤，即黏膜下纤维化和异物反应，在高剂量动物中变得更为普遍。异物反应在暴露后4周时存在于所有动物中，似乎是由于毛发和/或饲料颗粒在愈合过程中被困在前胃损伤中所致。据推测，细胞增殖增加和诱导的异物反应可能促成了先前已证明的EtAc对大鼠前胃的致癌作用。
