Bracey A W, Van Buren C
Transfusion. 1986 May-Jun;26(3):282-4. doi: 10.1046/j.1537-2995.1986.26386209389.x.
Antibodies specific for recipient red cell antigens have been demonstrated in patients who receive organs from ABO unmatched donors. In some cases, severe but self-limited hemolysis has been associated with the development of posttransplantation antibodies. We report a case in which an A2 recipient of a kidney from a group O donor formed anti-A1 antibody which reacted with homologous red cells. The patient developed a delayed hemolytic transfusion reaction. A radiochromium survival study revealed decreased survival of A1 red cells. A broader specificity of the antibody was not shown during follow-up. The anti-A1 was not detected in a sample tested 6 months after the initial study. It is probable that the anti-A1 noted in this case was formed by passenger lymphocytes. A2 patients who develop anti-A1 after renal transplantation should be transfused with red cells negative for A1.
在接受来自 ABO 血型不匹配供体器官的患者体内已证实存在针对受者红细胞抗原的抗体。在某些情况下，严重但自限性的溶血与移植后抗体的产生有关。我们报告了一例病例，一名 O 型供体肾脏的 A2 型受者形成了与同源红细胞发生反应的抗 A1 抗体。该患者发生了迟发性溶血性输血反应。放射性铬存活研究显示 A1 型红细胞的存活率降低。随访期间未发现该抗体具有更广泛的特异性。在初始研究 6 个月后的一份检测样本中未检测到抗 A1 抗体。该病例中发现的抗 A1 抗体很可能是由过客淋巴细胞形成的。肾移植后产生抗 A1 抗体的 A2 型患者应输注 A1 阴性的红细胞。
