Kentucky College of Osteopathic Medicine, University of Pikeville, A: 147 Sycamore Street, Pikeville, KY, 41501, USA.
College of Osteopathic Medicine, Kansas City University, Kansas City, MO, USA.
Acta Neurol Belg. 2022 Apr;122(2):305-314. doi: 10.1007/s13760-022-01889-1. Epub 2022 Feb 19.
Peri-intraventricular hemorrhage (PIVH) is a serious condition for preterm infants, caused by traumatic or spontaneous rupture of the germinal matrix (GM) capillary network in the cerebral ventricles. It is a common source of morbidity and mortality in neonates, and risk correlates with earlier delivery, low birth weight, maternal-fetal infection, and vital sign derangements, among others. PIVH typically occurs in the first 72 h of life, and symptoms, when present, manifest most commonly within the first week of life. Prevention remains the primary goal in management, predominantly via prolonging of gestation. Current therapy protocols are center-dependent without consistent consensus guidelines, but infant positioning, homeostatic stabilization, and neuroprotection offer potential options. In this update of pharmacologic neuroprotective therapies for PIVH, we highlight commonly utilized therapies and review the investigative literature. Further multi-institutional clinical trials and basic research studies are required.
脑室周围出血（PIVH）是早产儿的一种严重疾病，由脑室内室管膜下毛细血管网的创伤性或自发性破裂引起。它是新生儿发病率和死亡率的常见原因，其风险与早产、低出生体重、母婴感染和生命体征紊乱等因素有关。PIVH 通常发生在出生后的前 72 小时内，当出现症状时，最常见于生命的第一周内。预防仍然是管理的主要目标，主要通过延长妊娠期来实现。目前的治疗方案因中心而异，没有一致的共识指南，但婴儿体位、内稳态稳定和神经保护提供了潜在的选择。在本次更新的 PIVH 药物神经保护治疗中，我们重点介绍了常用的治疗方法，并回顾了相关的研究文献。还需要进行更多的多机构临床试验和基础研究。
