Sinzinger H, Kaliman J, Joskovics G
Wien Klin Wochenschr. 1986 Feb 21;98(4):107-10.
Since the original discovery and structural characterization of leukotrienes, these substances have attracted considerable interest due to their numerous biological activities. It is known that these substances exert a short lasting vasoconstrictory and a longer lasting vasodilatory response. However, the cause of this biphasic response is not clear as yet. Human coronary artery segments synthesize about 50 pg PGI2/cm2/min in vitro under pressure perfusion. At concentrations ranging from 1 to 100 ng leukotrienes C4 and D4 cause a dose-dependent increase in PGI2 generation. Inhibition by acetylsalicylic acid and 15-hydroxyperoxyarachidonic acid indicates the mechanism to be mediated via the cyclooxygenase. It is, therefore, concluded that the capacity of leukotrienes C4 and D4 to stimulate PGI2 formation might play a key role during acute inflammation at the site of white blood cell accumulation.
自从最初发现白三烯并对其进行结构表征以来，这些物质因其众多的生物学活性而引起了相当大的关注。已知这些物质会产生短暂的血管收缩反应和持续时间较长的血管舒张反应。然而，这种双相反应的原因尚不清楚。在压力灌注下，人冠状动脉节段在体外每分钟每平方厘米合成约50皮克前列环素（PGI2）。白三烯C4和D4在1至100纳克的浓度范围内会导致PGI2生成呈剂量依赖性增加。乙酰水杨酸和15 - 羟基过氧花生四烯酸的抑制作用表明该机制是通过环氧化酶介导的。因此，可以得出结论，白三烯C4和D4刺激PGI2形成的能力可能在白细胞聚集部位的急性炎症过程中起关键作用。
