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宿主-微生物糖相互作用的结构见解。

Structural insights into host-microbe glycointeractions.

作者信息

Lundstrøm Jon, Bojar Daniel

机构信息

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: https://twitter.com/jonlundstrm.

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.

出版信息

Curr Opin Struct Biol. 2022 Apr;73:102337. doi: 10.1016/j.sbi.2022.102337. Epub 2022 Feb 16.

DOI:10.1016/j.sbi.2022.102337
PMID:35182928
Abstract

Despite their ubiquitous presence in biological systems, glycans have historically received less attention than they deserved. Investigations in recent years have featured important findings about the role of glycans in regulating the human gut microbiota. Here, we present a brief overview of current trends that shape future directions of computational and experimental research approaches and add to our understanding of host-microbe glycointeractions.

摘要

尽管聚糖在生物系统中普遍存在,但从历史上看,它们受到的关注与其应得的关注度相比要少。近年来的研究取得了关于聚糖在调节人类肠道微生物群中作用的重要发现。在此,我们简要概述塑造计算和实验研究方法未来方向的当前趋势,并增进我们对宿主 - 微生物糖相互作用的理解。

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