Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China.
Department of Physiology, School of Life Science, China Medical University, Shenyang, China.
Tissue Cell. 2022 Jun;76:101746. doi: 10.1016/j.tice.2022.101746. Epub 2022 Jan 29.
Skin is a natural barrier of human body and a visual indicator of aging process. Exposure to ultraviolet (UV) radiation in the sunlight may injure the skin tissues and cause local damage. Besides, it is reported that repetitive or long-term exposure to UV radiation may reduce the collagen production, change the normal skin structure and cause premature skin aging. This is termed "photoaging". The classical symptoms of photoaging include increased roughness, wrinkle formation, mottled pigmentation or even precancerous changes. Mesenchymal stem cells (MSCs) are a kind of cells with the ability of self-renewal and multidirectional differentiation into many types of cells, like adipocytes, osteoblasts and chondrocytes. Researchers have explored diverse pharmacological actions of MSCs because of their migratory activity, paracrine actions and immunoregulation effects. In recent years, the huge potential of MSCs in preventing skin from photoaging has gained wide attention. MSCs exert their beneficial effects on skin photoaging via antioxidant effect, anti-apoptotic/anti-inflammatory effect, reduction of matrix metalloproteinases (MMPs) and activation of dermal fibroblasts proliferation. MSCs and MSC related products have demonstrated huge potential in the treatment of skin photoaging. This narrative review concisely sums up the recent research developments on the roles of MSCs in protection against photoaging and highlights the enormous potential of MSCs in skin photoaging treatment.
皮肤是人体的天然屏障，也是衰老过程的直观指标。阳光中的紫外线（UV）辐射会伤害皮肤组织，造成局部损伤。此外，据报道，反复或长期暴露于 UV 辐射可能会减少胶原蛋白的产生，改变正常的皮肤结构，导致皮肤过早衰老。这被称为“光老化”。光老化的典型症状包括粗糙度增加、皱纹形成、斑驳的色素沉着，甚至癌前病变。间充质干细胞（MSCs）是一种具有自我更新和多向分化为多种细胞（如脂肪细胞、成骨细胞和软骨细胞）能力的细胞。由于其迁移活性、旁分泌作用和免疫调节作用，研究人员已经探索了 MSCs 的多种药理作用。近年来，MSCs 在预防皮肤光老化方面的巨大潜力引起了广泛关注。MSCs 通过抗氧化作用、抗凋亡/抗炎作用、减少基质金属蛋白酶（MMPs）和激活真皮成纤维细胞增殖来发挥其对皮肤光老化的有益作用。MSCs 和 MSC 相关产品在治疗皮肤光老化方面显示出巨大的潜力。本综述简要总结了 MSCs 在预防光老化中的作用的最新研究进展，并强调了 MSCs 在皮肤光老化治疗中的巨大潜力。
