Lei Lanjie, Zhou Shaoyu, Zeng Lingyao, Gu Qiancheng, Xue Huaqian, Wang Fangyan, Feng Jiayin, Cui Shumao, Shi Liyun
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou 310015, China.
The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
Biomater Res. 2025 May 9;29:0148. doi: 10.34133/bmr.0148. eCollection 2025.
Exosomes (Exos) are tiny extracellular vesicles containing a variety of active biomolecules that play important parts in intercellular communication and influence the functions of target cells. The potential of Exos in the treatment of dermatological diseases has recently been well appreciated. This review highlights the constituents, function, and delivery of Exos, with a particular focus on their applications in skin therapy. Firstly, we offer a concise overview of the biochemical properties of Exos, including their sources, structures, and internal constituents. Subsequently, the biomedical functions of Exos and the latest advances in the extraction and purification of Exos are summarized. We further discuss the modes of delivery of Exos and underscore the potential of biomaterials in this regard. Finally, we summarize the application of Exo-aided therapy in dermatology. Overall, the objective of this review is to provide a comprehensive perspective on the applications and recent advancements of Exo-based approaches in treating skin diseases, with the intention of guiding future research efforts.
外泌体（Exos）是微小的细胞外囊泡，含有多种活性生物分子，在细胞间通讯中发挥重要作用，并影响靶细胞的功能。外泌体在皮肤病治疗中的潜力最近已得到充分认识。本综述重点介绍了外泌体的成分、功能和递送方式，特别关注其在皮肤治疗中的应用。首先，我们简要概述了外泌体的生化特性，包括其来源、结构和内部成分。随后，总结了外泌体的生物医学功能以及外泌体提取和纯化的最新进展。我们进一步讨论了外泌体的递送方式，并强调了生物材料在这方面的潜力。最后，我们总结了外泌体辅助疗法在皮肤病学中的应用。总体而言，本综述的目的是全面介绍基于外泌体的方法在治疗皮肤疾病中的应用和最新进展，以期指导未来的研究工作。
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