Department of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510999, China; Department of Nephrology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510999, China.
State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China.
Metabolism. 2022 May;130:155166. doi: 10.1016/j.metabol.2022.155166. Epub 2022 Feb 18.
Fibroblast growth factor 21 is an evolutionarily conserved factor that plays multiple important roles in metabolic homeostasis. During the past two decades, extensive investigations have improved our understanding of its delicate metabolic roles and identified its pharmacological potential to mitigate metabolic disorders. However, most clinical trials have failed to obtain the desired results, which raises issues regarding its clinical value. Fibroblast growth factor 21 is dynamically regulated by nutrients derived from food intake and hepatic/adipose release, which in turn act on the central nervous system, liver, and adipose tissues to influence food preference, hepatic glucose, and adipose fatty acid output. Based on this information, we propose that fibroblast growth factor 21 should not be considered merely an anti-hyperglycemia or anti-obesity factor, but rather a means of balancing of nutrient fluctuations to maintain an appropriate energy supply. Hence, the specific functions of fibroblast growth factor 21 in glycometabolism and lipometabolism depend on specific metabolic states, indicating that its pharmacological effects require further consideration.
成纤维细胞生长因子 21 是一种进化上保守的因子，在代谢稳态中发挥多种重要作用。在过去的二十年中，广泛的研究提高了我们对其微妙代谢作用的理解，并确定了其药理学潜力，以减轻代谢紊乱。然而，大多数临床试验未能获得预期的结果，这引发了关于其临床价值的问题。成纤维细胞生长因子 21 受到来自食物摄入和肝脏/脂肪释放的营养素的动态调节，这些营养素反过来作用于中枢神经系统、肝脏和脂肪组织，影响食物偏好、肝脏葡萄糖和脂肪组织脂肪酸的输出。基于这些信息，我们提出成纤维细胞生长因子 21 不应仅仅被视为抗高血糖或抗肥胖因子，而是一种平衡营养波动以维持适当能量供应的手段。因此，成纤维细胞生长因子 21 在糖代谢和脂代谢中的特定功能取决于特定的代谢状态，表明其药理学作用需要进一步考虑。
