通过靶向CHI3L1/ITGA5轴治疗特应性皮炎的新策略。 - Suppr

New therapeutic strategy for atopic dermatitis by targeting CHI3L1/ITGA5 axis.

作者信息

Lee Yong Sun, Yu Ji Eun, Kim Min Ji, Ham Hyeon Joo, Jeon Seong Hee, Yun Jaesuk, Song Suk-Gil, Lee Chong-Kil, Han Sang Bae, Son Dong Ju, Hong Jin Tae

机构信息

College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Republic of Korea.

出版信息

Clin Transl Med. 2022 Feb;12(2):e739. doi: 10.1002/ctm2.739.

DOI:10.1002/ctm2.739

PMID:35184414

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858621/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c053/8858621/d2f9a69a7221/CTM2-12-e739-g002.jpg

相似文献

New therapeutic strategy for atopic dermatitis by targeting CHI3L1/ITGA5 axis.

Clin Transl Med. 2022 Feb;12(2):e739. doi: 10.1002/ctm2.739.

SPINK5 is associated with early-onset and CHI3L1 with late-onset atopic dermatitis.

Int J Immunogenet. 2017 Oct;44(5):212-218. doi: 10.1111/iji.12327. Epub 2017 Jul 6.

Chitinase 3-like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation.

Clin Exp Allergy. 2019 Nov;49(11):1464-1474. doi: 10.1111/cea.13478. Epub 2019 Aug 28.

Consensus Conference Management of atopic dermatitis in children. Recommendations (short version).

Eur J Dermatol. 2005 Jul-Aug;15(4):215-23.

[Indications for sunflower oil concentrate in the treatment of atopic dermatitis].

Rev Alerg Mex. 2006 Nov-Dec;53(6):217-25.

Suppression of the HPA axis in pediatric patients with atopic dermatitis.

Arch Dermatol. 2007 Nov;143(11):1449-50. doi: 10.1001/archderm.143.11.1449-b.

Novel therapies based on the pathophysiology of atopic dermatitis.

J Dtsch Dermatol Ges. 2019 Nov;17(11):1150-1162. doi: 10.1111/ddg.13965.

[New treatments for atopic dermatitis].

Lakartidningen. 2017 Nov 21;114:EU3D.

[Recent advances of pathophysiology and treatment of atopic dermatitis].

Arerugi. 1996 Oct;45(10):1075-81.

[Leukotriene receptor antagonists--possible therapeutic option in the treatment of atopic dermatitis ].

Pol Merkur Lekarski. 2003 Jan;14(79):86-8.

引用本文的文献

Chitinase-3-Like Protein 1 as a Therapeutic Target for Inflammatory Diseases.

Biomol Ther (Seoul). 2025 Sep 1;33(5):747-757. doi: 10.4062/biomolther.2025.050. Epub 2025 Aug 7.

Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3.

Immune Netw. 2025 Feb 7;25(2):e5. doi: 10.4110/in.2025.25.e5. eCollection 2025 Apr.

Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential.

Res Sq. 2024 May 30:rs.3.rs-4462139. doi: 10.21203/rs.3.rs-4462139/v1.

Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data.

Aging (Albany NY). 2024 Mar 22;16(7):5949-5966. doi: 10.18632/aging.205682.

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer.

Exp Mol Med. 2024 Feb;56(1):1-18. doi: 10.1038/s12276-023-01131-9. Epub 2024 Jan 4.

Chitinase-3-like 1 regulates T2 cells, T cells and IgE responses to helminth infection.

Front Immunol. 2023 Jul 27;14:1158493. doi: 10.3389/fimmu.2023.1158493. eCollection 2023.

Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions.

Biol Res. 2023 May 10;56(1):23. doi: 10.1186/s40659-023-00437-2.

ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma.

Iran J Basic Med Sci. 2023 Feb;26(2):200-207. doi: 10.22038/IJBMS.2022.67056.14703.

本文引用的文献

Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin.

Immune Netw. 2021 Jun 29;21(3):e22. doi: 10.4110/in.2021.21.e22. eCollection 2021 Jun.

Serum receptor activator of nuclear factor kappa-Β ligand/osteoprotegerin ratio correlates with severity and suggests fracture's risk in older women with atopic dermatitis.

Allergy. 2021 Oct;76(10):3220-3223. doi: 10.1111/all.14971. Epub 2021 Jun 15.

Chitinase-3 like-protein-1 function and its role in diseases.

Signal Transduct Target Ther. 2020 Sep 14;5(1):201. doi: 10.1038/s41392-020-00303-7.

Chitinase 3-like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation.

Clin Exp Allergy. 2019 Nov;49(11):1464-1474. doi: 10.1111/cea.13478. Epub 2019 Aug 28.

SPINK5 is associated with early-onset and CHI3L1 with late-onset atopic dermatitis.

Int J Immunogenet. 2017 Oct;44(5):212-218. doi: 10.1111/iji.12327. Epub 2017 Jul 6.

Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis.

J Immunol Res. 2017;2017:5746031. doi: 10.1155/2017/5746031. Epub 2017 Jun 4.

Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.

Oncotarget. 2015 Nov 3;6(34):36535-50. doi: 10.18632/oncotarget.5440.

YKL-40, a secreted glycoprotein, promotes tumor angiogenesis.

Oncogene. 2009 Dec 17;28(50):4456-68. doi: 10.1038/onc.2009.292. Epub 2009 Sep 21.

Integrins.

Cell Tissue Res. 2010 Jan;339(1):269-80. doi: 10.1007/s00441-009-0834-6. Epub 2009 Aug 20.

Adhesion molecules in atopic dermatitis: upregulation of alpha6 integrin expression in spontaneous lesional skin as well as in atopen, antigen and irritative induced patch test reactions.

Int Arch Allergy Immunol. 1997 Aug;113(4):495-504. doi: 10.1159/000237628.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

New therapeutic strategy for atopic dermatitis by targeting CHI3L1/ITGA5 axis.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献