几丁质酶 3 样蛋白 1 调节 T2 细胞、T 细胞和 IgE 对寄生虫感染的反应。
Chitinase-3-like 1 regulates T2 cells, T cells and IgE responses to helminth infection.
机构信息
Department of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Department of Medicine, Section of Allergy and Immunology, Birmingham VA Medical Center, Birmingham, AL, United States.
出版信息
Front Immunol. 2023 Jul 27;14:1158493. doi: 10.3389/fimmu.2023.1158493. eCollection 2023.
INTRODUCTION
Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.
METHODS
To address whether Chi3l1 also contributes to T2 responses following nematode infection, we infected mice with () and analyzed T cell responses.
RESULTS
As anticipated, we observed impaired T2 responses in -infected mice. However, we also found that T cell intrinsic expression of was required for ICOS upregulation following activation of naïve CD4 T cells and was necessary for the development of the IL-4 T subset, which supports germinal center B cell reactions and IgE responses. We also observed roles for in T, germinal center B cell, and IgE responses to alum-adjuvanted vaccination. While was critical for IgE humoral responses it was not required for vaccine or infection-induced IgG1 responses.
DISCUSSION
These results suggest that modulates IgE responses, which are known to be highly dependent on IL-4-producing T cells.
简介
特应性皮炎、食物过敏和哮喘患者队列和小鼠模型的数据强烈支持几丁质酶 3 样蛋白 1（CHI3L1）在过敏疾病中的作用。
方法
为了确定 Chi3l1 是否也参与线虫感染后的 T2 反应，我们用（）感染小鼠，并分析了 T 细胞反应。
结果
正如预期的那样，我们观察到在感染的小鼠中 T2 反应受损。然而，我们还发现，在激活幼稚 CD4 T 细胞后，ICOS 的上调需要细胞内表达，这对于支持生发中心 B 细胞反应和 IgE 反应的 IL-4 T 亚群的发育是必要的。我们还观察到在针对铝佐剂的疫苗接种的 T、生发中心 B 细胞和 IgE 反应中，起着作用。虽然对于 IgE 体液反应非常关键，但对于疫苗或感染诱导的 IgG1 反应则不是必需的。
讨论
这些结果表明，调节 IgE 反应，而 IgE 反应已知高度依赖于产生 IL-4 的 T 细胞。
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