长链非编码 RNA RGMB-AS1 通过与叉头框蛋白 A1 结合抑制鼻咽癌的进展。
Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1.
机构信息
Department of ENT and HN Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, PR China.
Department of ENT and HN Surgery, Central People's Hospital of ZhanJiang, ZhanJiang, PR China.
出版信息
Bioengineered. 2022 Mar;13(3):5564-5580. doi: 10.1080/21655979.2022.2039495.
Long non-coding RNA RGMB-AS1 (RGMB antisense RNA 1) plays a crucial role in tumor progression. However, its underlying mechanism in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we analyzed the clinical significance of lncRNA RGMB-AS1 as a possible potential marker in NPC, and investigated the effect and mechanism of lncRNA RGMB-AS1 on proliferation, migration and epithelial mesenchymal transformation (EMT) of NPC by directly binding Forkhead box A1 (FOXA1) in and in . In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis.
长链非编码 RNA RGMB-AS1（RGMB 反义 RNA1）在肿瘤进展中起着关键作用。然而，其在鼻咽癌（NPC）中的潜在机制尚不清楚。在本研究中，我们分析了 lncRNA RGMB-AS1 作为 NPC 中一种可能的潜在标志物的临床意义，并通过直接结合 Forkhead box A1（FOXA1）在 NPC 中探讨了 lncRNA RGMB-AS1 对 NPC 增殖、迁移和上皮间质转化（EMT）的影响和机制。总之，LncRNA RGMB-AS1 通过调节 FOXA1 抑制恶性行为和 EMT，lncRNA RGMB-AS1 可能是临床预后的重要指标。
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