基于腺病毒载体的疫苗与格林-巴利综合征：一种提出的机制。
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism.
作者信息
Kadkhoda Kamran
机构信息
Immunopathology Laboratory, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, USA.
出版信息
Med Hypotheses. 2022 Mar;160:110792. doi: 10.1016/j.mehy.2022.110792. Epub 2022 Feb 12.
Abstract
Despite great public health advances achieved by COVID-19 vaccines, rare side effects may impact the public acceptance. Guillain-Barre Syndrome has increasingly been reported with adenoviral-based vaccines. This perspective proposes a possible mechanism underlying this rare but clinically significant side effect thereby providing insights for improving our current vaccines against COVID-19.
摘要
尽管新冠疫苗在公共卫生方面取得了巨大进展，但罕见的副作用可能会影响公众的接受度。越来越多的报告指出，基于腺病毒的疫苗会引发吉兰-巴雷综合征。本文观点提出了这种罕见但具有临床意义的副作用背后的一种可能机制，从而为改进我们目前的新冠疫苗提供见解。
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