Krugliakova Elena, Skorucak Jelena, Sousouri Georgia, Leach Sven, Snipes Sophia, Ferster Maria Laura, Da Poian Giulia, Karlen Walter, Huber Reto
Child Development Centre and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Mobile Health Systems Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland.
Front Neurosci. 2022 Feb 2;16:755958. doi: 10.3389/fnins.2022.755958. eCollection 2022.
Sufficient recovery during sleep is the basis of physical and psychological well-being. Understanding the physiological mechanisms underlying this restorative function is essential for developing novel approaches to promote recovery during sleep. Phase-targeted auditory stimulation (PTAS) is an increasingly popular technique for boosting the key electrophysiological marker of recovery during sleep, slow-wave activity (SWA, 1-4 Hz EEG power). However, it is unknown whether PTAS induces physiological sleep. In this study, we demonstrate that, when applied during deep sleep, PTAS accelerates SWA decline across the night which is associated with an overnight improvement in attentional performance. Thus, we provide evidence that PTAS enhances physiological sleep and demonstrate under which conditions this occurs most efficiently. These findings will be important for future translation into clinical populations suffering from insufficient recovery during sleep.
睡眠期间的充分恢复是身心健康的基础。了解这种恢复功能背后的生理机制对于开发促进睡眠期间恢复的新方法至关重要。相位靶向听觉刺激（PTAS）是一种越来越流行的技术，用于增强睡眠期间恢复的关键电生理指标，即慢波活动（SWA，1-4Hz脑电图功率）。然而，尚不清楚PTAS是否能诱导生理性睡眠。在本研究中，我们证明，在深度睡眠期间应用PTAS时，它会加速夜间SWA的下降，这与注意力表现的夜间改善有关。因此，我们提供了证据表明PTAS可增强生理性睡眠，并证明了在何种条件下这种效果最为显著。这些发现对于未来转化应用于睡眠恢复不足的临床人群具有重要意义。
