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血清外泌体 lncRNA AC007099.1 调节神经肽相关 FAP 的表达，作为肝癌发生的潜在生物标志物。

Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis.

机构信息

Department of Clinical Laboratory Medicine Maoming People's Hospital, China.

出版信息

Dis Markers. 2022 Feb 10;2022:9501008. doi: 10.1155/2022/9501008. eCollection 2022.

DOI:10.1155/2022/9501008
PMID:35186170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8853759/
Abstract

Neuropeptide-associated fibroblast activation protein (FAP) may be an important risk factor for neurovascular metastasis in hepatocellular carcinoma. Analysis of The Cancer Genome Atlas (TCGA) database showed that mRNA was highly expressed in most human tumor tissues. The HPA database then verified that was highly expressed in tumor tissues following protein translation. Survival analysis then showed that the level of expression significantly affected the overall survival (OS), progress free interval (PFI), and disease specific survival (DSS) of patients with hepatocellular carcinoma. A high expression of in tumor tissue is associated with poor patient prognosis. According to the results of spearman correlation, AC009099 and were negatively correlated with miR-7152 expression, while AC009099 and expression were positively correlated. The lncRNA AC007099.1, which may serve as a potential target for the treatment of hepatocellular carcinoma, was associated with liver cancer. AC007099.1/miR-7152/FAP was found to be associated with immune infiltration in patients with hepatocellular carcinoma. Enrichment analysis suggests that the AC009099/miR-7152/FAP ceRNA regulatory network is associated with neuropeptide functional pathways. In conclusion, a neuropeptide-related AC009099/miR-7152/FAP ceRNA regulatory network was constructed in this study.

摘要

神经肽相关成纤维细胞激活蛋白 (FAP) 可能是肝癌神经血管转移的重要危险因素。对癌症基因组图谱 (TCGA) 数据库的分析表明， 在大多数人类肿瘤组织中高表达。HPA 数据库随后验证了 在蛋白质翻译后在肿瘤组织中高表达。生存分析表明， 表达水平显著影响肝癌患者的总生存期 (OS)、无进展间隔 (PFI) 和疾病特异性生存期 (DSS)。肿瘤组织中 的高表达与患者预后不良相关。根据 spearman 相关性分析的结果，AC009099 与 miR-7152 的表达呈负相关，而 AC009099 与 的表达呈正相关。lncRNA AC007099.1 可能作为肝癌的潜在治疗靶点，与肝癌相关。AC007099.1/miR-7152/FAP 与肝癌患者的免疫浸润有关。富集分析表明，AC009099/miR-7152/FAP ceRNA 调控网络与神经肽功能途径有关。总之，本研究构建了一个与神经肽相关的 AC009099/miR-7152/FAP ceRNA 调控网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/5d1f75abf354/DM2022-9501008.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/8970c91fd3f9/DM2022-9501008.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/83f99f128714/DM2022-9501008.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/a40a3ec651dc/DM2022-9501008.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/69d360060c9b/DM2022-9501008.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/785198896812/DM2022-9501008.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/5d1f75abf354/DM2022-9501008.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/8970c91fd3f9/DM2022-9501008.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/83f99f128714/DM2022-9501008.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/a40a3ec651dc/DM2022-9501008.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/69d360060c9b/DM2022-9501008.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/785198896812/DM2022-9501008.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/8853759/5d1f75abf354/DM2022-9501008.006.jpg

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本文引用的文献

1
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Oxid Med Cell Longev. 2021 Dec 29;2021:8302831. doi: 10.1155/2021/8302831. eCollection 2021.
2
An integrative microenvironment approach for laryngeal carcinoma: the role of immune/methylation/autophagy signatures on disease clinical prognosis and single-cell genotypes.一种针对喉癌的综合微环境方法：免疫/甲基化/自噬特征在疾病临床预后和单细胞基因型中的作用。
J Cancer. 2021 May 13;12(14):4148-4171. doi: 10.7150/jca.58076. eCollection 2021.
3
成纤维细胞激活蛋白-α在类风湿关节炎成纤维样滑膜细胞表面表达的作用及机制。
Front Immunol. 2023 Mar 17;14:1135384. doi: 10.3389/fimmu.2023.1135384. eCollection 2023.
4
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Front Genet. 2022 Aug 17;13:953580. doi: 10.3389/fgene.2022.953580. eCollection 2022.
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4
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