沙特发作性睡病患者的医学合并症：一项病例对照研究。
Medical comorbidities in Saudi patients with narcolepsy: a case-control study.
作者信息
BaHammam Ahmed Salem, Olaish Awad H, Al-Omar Majid, Almeneessier Aljohara S
机构信息
King Saud University, University Sleep Disorders Center, Department of Medicine, College of Medicine - Riyadh - Riyadh - Saudi Arabia.
Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia, National Plan - Riyadh - Riyadh - Saudi Arabia.
出版信息
Sleep Sci. 2021 Jul-Sep;14(3):286-290. doi: 10.5935/1984-0063.20200070.
OBJECTIVE
This case-control study sought to assess comorbid medical disorders in patients with narcolepsy type-1 (NT-1) and type-2 (NT-2).
MATERIAL AND METHODS
The study comprised 80 consecutive Arab (Saudi) patients with narcolepsy (NT-1=56 and NT-2=24) and a control group of 211 adults matched for age, sex, and body mass index (BMI). Data were collected from cases and controls based on a predesigned questionnaire that was formulated based on previous studies to evaluate the chosen medical comorbidities.
RESULTS
Narcolepsy patients had a higher prevalence of hypothyroidism and hyperlipidemia and a higher prevalence of high-risk for OSA than controls. Hyperlipidemia was more common in cases than controls, 8 (10%) vs. 3 (1.4%), p=0.002. After adjusting for age, sex, and BMI, the odds-ratios for hypothyroidism and high risk for OSA in the NT-1 group was 5.49 (95% CI, [0.8 - 38.6]) and 69.99 ((95%CI [20.6 -237.4]), respectively, and in the NT-2 group, 12.5, 95%CI [1.6-97.7], and 33.3, 95%CI [8.2-135.7], respectively.
CONCLUSION
Arab (Saudi) narcolepsy patients had a higher association with hypothyroidism, hyperlipidemia, and a higher risk of OSA than controls.
目的
本病例对照研究旨在评估1型发作性睡病（NT - 1）和2型发作性睡病（NT - 2）患者的合并内科疾病。
材料与方法
该研究纳入了80例连续的阿拉伯（沙特）发作性睡病患者（NT - 1 = 56例，NT - 2 = 24例）以及211名年龄、性别和体重指数（BMI）相匹配的成年对照组。基于之前的研究设计了一份预先设计好的问卷，从病例组和对照组收集数据，以评估所选的合并内科疾病。
结果
发作性睡病患者甲状腺功能减退症和高脂血症的患病率较高，阻塞性睡眠呼吸暂停（OSA）高风险的患病率也高于对照组。高脂血症在病例组中比对照组更常见，分别为8例（10%）和3例（1.4%），p = 0.002。在调整年龄、性别和BMI后，NT - 1组甲状腺功能减退症和OSA高风险的优势比分别为5.49（95%可信区间，[0.8 - 38.6]）和69.99（95%可信区间[20.6 - 237.4]），NT - 2组分别为12.5（95%可信区间[1.6 - 97.7]）和33.3（95%可信区间[8.2 - 135.7]）。
结论
阿拉伯（沙特）发作性睡病患者与甲状腺功能减退症、高脂血症的关联更高，且OSA风险高于对照组。
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