School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Ophthalmology. 2010 Nov;117(11):2088-95. doi: 10.1016/j.ophtha.2010.03.003. Epub 2010 Jun 8.
To determine the prevalence of selected comorbidities in patients with open-angle glaucoma (OAG) and whether these comorbidities are more prevalent among individuals with OAG than those without OAG.
A retrospective, nationwide, case-control study using an administrative database.
The study group comprised 76,673 OAG patients. The comparison group comprised 230,019 subjects matched to the study cohort.
Data were collected retrospectively from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification codes 365.1-365.11) in 2005 (n = 76,673). The comparison cohort comprised randomly selected patients (3 for every 1 OAG patient; n = 230,019) matched with the study group in terms of age, gender, urbanization level, and monthly income. In total, 31 medical comorbidities were selected based mainly on the Elixhauser Comorbidity Index. Separate conditional logistic regression analyses were used to estimate the adjusted odds ratio for each of the medical comorbidities between patients with and without OAG.
The prevalences of selected comorbidities.
More than half (50.5%) of the OAG patients had hypertension, and more than 30% had hyperlipidemia or diabetes (30.5% and 30.2%, respectively). The prevalences of 28 of 31 comorbidities were significantly higher for OAG patients than subjects without glaucoma after adjusting for age, gender, urbanization level, and monthly income. The adjusted odds ratio was more than 1.50 for hypertension, hyperlipidemia, systemic lupus erythematosus, diabetes, hypothyroidism, fluid and electrolyte disorders, depression, and psychosis. Among the studied comorbidities, the prevalence difference of the OAG group minus the control group was 3% or higher for hypertension, hyperlipidemia, stroke, diabetes, liver disease, and peptic ulcer.
Open-angle glaucoma patients are significantly more likely to have comorbidities, many of which can be life threatening or can affect the quality of life appreciably.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussedin this article
确定开角型青光眼（OAG）患者中某些合并症的患病率，以及这些合并症在 OAG 患者中是否比非 OAG 患者更为普遍。
一项使用管理数据库的回顾性、全国性病例对照研究。
研究组包括 76673 例 OAG 患者。对照组包括 230019 名与研究队列相匹配的受试者。
数据从台湾全民健康保险研究数据库中回顾性收集。研究队列包括 2005 年所有诊断为 OAG（国际疾病分类，第 9 版，临床修正版代码 365.1-365.11）的患者（n=76673）。对照组包括根据年龄、性别、城市化水平和月收入与研究组相匹配的随机选择的患者（每 1 例 OAG 患者 3 例；n=230019）。总共根据 Elixhauser 合并症指数主要选择了 31 种医疗合并症。分别采用条件逻辑回归分析来估计 OAG 患者与非 OAG 患者之间每种医疗合并症的调整后优势比。
选定合并症的患病率。
超过一半（50.5%）的 OAG 患者患有高血压，超过 30%的患者患有高血脂或糖尿病（分别为 30.5%和 30.2%）。在调整年龄、性别、城市化水平和月收入后，与无青光眼患者相比，OAG 患者中 31 种合并症中的 28 种的患病率显著更高。高血压、高血脂、系统性红斑狼疮、糖尿病、甲状腺功能减退症、体液和电解质紊乱、抑郁症和精神病的调整后优势比均大于 1.50。在所研究的合并症中，OAG 组与对照组之间的患病率差异为 3%或更高的包括高血压、高血脂、中风、糖尿病、肝病和消化性溃疡。
开角型青光眼患者发生合并症的可能性显著更高，其中许多合并症可能危及生命或显著影响生活质量。
作者没有任何与本文讨论的材料相关的专有或商业利益。
