Yi Minseok, Lee Jae Sung
Interdisciplinary Program in Bioengineering, Seoul National University College of Engineering, Seoul, 03080 South Korea.
Department of Nuclear Medicine, Seoul National University College of Medicine, Daehak-ro, 101, Jongno-gu, Seoul, 03080 South Korea.
Biomed Eng Lett. 2022 Jan 17;12(1):85-95. doi: 10.1007/s13534-022-00215-1. eCollection 2022 Feb.
We developed a time-based single-transmission-line readout method for time-of-flight positron emission tomography (PET) detectors. The 2D position of a silicon photomultiplier (SiPM) array was encoded in the upper and lower widths of a specially prepared L-shaped tag pulse followed by the original scintillation signal. A PET detector setup was configured using a 4 × 4 array of LSO crystals optically coupled one-to-one to a 4 × 4 SiPM array. Two pulse width modulator circuits were employed per SiPM anode signal channel and a total of 32 width-modulated digital pulses were summed and merged with a delayed common-cathode signal. The final output was analyzed using timestamps crossing two-level threshold voltages. All 16 crystals were clearly separated on a positioning map. The average energy and coincidence time resolutions were 15.0 ± 1.1% and 288.7 ± 29.3 ps after proper correction process, respectively. A 3D position decoding capability was also shown by the remarkable discrimination performance in a phoswich PET detector setup (LSO and LGSO), resulting from well-preserved scintillation signals. The proposed method enables a time-based single-channel readout with 3D gamma ray interaction position decoding capability without compromising on detector performance. This method provides gamma ray energy and arrival time information as well as 2D and depthwise interaction positions of the phoswich detectors through one channel readout. Thus, channels can be reduced by at least 4-5 times compared to typically employed charge-sharing-based position multiplexing method; this significantly reduces the burden of data acquisition on the PET system.
我们为飞行时间正电子发射断层扫描(PET)探测器开发了一种基于时间的单传输线读出方法。硅光电倍增管(SiPM)阵列的二维位置被编码在一个专门制备的L形标记脉冲的上下宽度中,随后是原始闪烁信号。使用一个4×4的LSO晶体阵列一对一光学耦合到一个4×4的SiPM阵列来配置PET探测器装置。每个SiPM阳极信号通道采用两个脉宽调制电路,总共32个宽度调制数字脉冲被求和并与一个延迟的共阴极信号合并。最终输出通过跨越两级阈值电压的时间戳进行分析。在定位图上所有16个晶体都能清晰分离。经过适当的校正处理后,平均能量分辨率和符合时间分辨率分别为15.0±1.1%和288.7±29.3 ps。在一个磷光体PET探测器装置(LSO和LGSO)中,由于闪烁信号得到良好保留,通过出色的鉴别性能也展示了三维位置解码能力。所提出的方法能够实现基于时间的单通道读出,具有三维伽马射线相互作用位置解码能力,而不会损害探测器性能。该方法通过单通道读出提供伽马射线能量和到达时间信息以及磷光体探测器的二维和深度方向相互作用位置。因此,与通常采用的基于电荷共享的位置复用方法相比,通道数可减少至少4至5倍;这显著减轻了PET系统的数据采集负担。