红细胞补体受体1基因多态性与新生儿呼吸窘迫综合征
Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome.
作者信息
Rabie Walaa, Al-Taweel Ahmed, Abuelhamd Walaa A, Shahin Walaa, Nazeer Marian, Aly Hany
机构信息
Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Pediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
J Pediatr Genet. 2020 Oct 5;11(1):15-21. doi: 10.1055/s-0040-1717108. eCollection 2022 Mar.
To evaluate the role of erythrocyte complement receptor 1 ( ) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days, = 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days, = 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of may be of little importance for RDS.
为评估红细胞补体受体1（ ）基因在呼吸窘迫综合征（RDS）易感性中的作用，我们研究了50例RDS婴儿和50例对照。对A3650G（rs2274567）进行实时聚合酶链反应等位基因鉴别分析，并对等位基因（HindIII）进行基因分型。与RDS严重程度相关的HindIII限制性单核苷酸多态性（SNP）的等位基因L。A3650G SNP的AA和AG基因型的吸氧和通气持续时间分别长于GG基因型（17.6±19.4天和8.6±4.5天， =0.01）和（8.9±11.9天和3.9±3.53天， =0.03）。 的A3650G和HINDIII消化基因多态性对RDS可能不太重要。
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