Cavarretta Elena, Sciarra Luigi, Biondi-Zoccai Giuseppe, Maffessanti Francesco, Nigro Antonia, Sperandii Fabio, Guerra Emanuele, Quaranta Federico, Fossati Chiara, Peruzzi Mariangela, Pingitore Annachiara, Stasinopoulos Dimitrios M, Rigby Robert A, Adorisio Rachele, Saglietto Andrea, Calò Leonardo, Frati Giacomo, Pigozzi Fabio
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Mediterranea Cardiocentro, Naples, Italy.
Front Cardiovasc Med. 2022 Feb 3;8:784170. doi: 10.3389/fcvm.2021.784170. eCollection 2021.
Very limited data exist on normal age-related ECG variations in adolescents and no data have been published regarding the ECG anomalies induced by intensive training, which are relevant in pre-participation screening for sudden cardiac death prevention in the adolescent athletic population. The purpose of this study was to establish normal age-related electrocardiographic measurements (P wave duration, PR interval, QRS duration, QT, and QTc interval) grouped according to 2-year age intervals.
A total of 2,151 consecutive healthy adolescent Soccer athletes (trained for a mean of 7.2 ± 1.1 h per week, 100% male Caucasians, mean age 12.4 ± 1.4 years, range 7-18) underwent pre-participation screening, which included ECG and transthoracic echocardiography in a single referral center.
Their heart rate progressively slowed as age increased ( < 0.001, ranging from 80.8 ± 13.2 to 59.5 ± 10.2 bpm), as expected. The P wave, PR interval, and QRS duration significantly increased in older age classes ( = 0.019, = 0.001, and < 0.001, respectively), and after Bonferroni's correction, the difference remained significant in all age classes for QRS duration. The QTc interval diminished progressively with increasing age ( = 0.003) while the QT interval increased progressively ( < 0.001).
Significant variations in the normal ECG characteristics of young athletes exist between different age groups related to increasing age and training burden, thus, age-specific reference values could be adopted, as already done for echocardiographic measurements, and may help to further discriminate potentially pathologic conditions.
关于青少年正常的年龄相关心电图变化的数据非常有限,且尚未有关于强化训练引起的心电图异常的数据发表,而这些异常在青少年运动员群体的参与前心脏猝死预防筛查中具有重要意义。本研究的目的是建立按2岁年龄间隔分组的正常年龄相关心电图测量值(P波时限、PR间期、QRS时限、QT和QTc间期)。
共有2151名连续的健康青少年足球运动员(平均每周训练7.2±1.1小时,均为男性白种人,平均年龄12.4±1.4岁,范围7 - 18岁)在单一转诊中心接受了参与前筛查,包括心电图和经胸超声心动图检查。
正如预期的那样,随着年龄的增加,他们的心率逐渐减慢(P<0.001,范围从80.8±13.2次/分钟到59.5±10.2次/分钟)。P波、PR间期和QRS时限在年龄较大的组中显著增加(分别为P = 0.019、P = 0.001和P<0.001),在Bonferroni校正后,QRS时限在所有年龄组中的差异仍然显著。QTc间期随着年龄的增加而逐渐减小(P = 0.003),而QT间期逐渐增加(P<0.001)。
年轻运动员正常心电图特征在不同年龄组之间存在显著差异,这与年龄增长和训练负担有关,因此,可以采用特定年龄的参考值,就像超声心动图测量那样,这可能有助于进一步区分潜在的病理状况。