Flores-Hidalgo Andres, Bankhead Alec, Murrah Valerie, Padilla Ricardo
Department of Surgical Sciences, Division of Oral and Maxillofacial Pathology, East Carolina University School of Dental Medicine, Greenville, NC, United States.
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Front Oral Health. 2022 Feb 3;3:802555. doi: 10.3389/froh.2022.802555. eCollection 2022.
Report of the incidence of malignant hematologic neoplasms in the oral cavity according to the experience of the two oral and maxillofacial pathology institutions in North Carolina, USA.
A 10-year retrospective review was carried out in the records of patients at ECU SoDM and UNC Adams SoD. Age, sex, location of the lesion, clinical impression, initial diagnosis, and the expression immunohistochemical and molecular markers were recorded for each subject. All diagnoses were reviewed according to the 2016 revision of the WHO classification of lymphoid neoplasms.
A total of 318 records from both institutions were reviewed. Seventy males and 68 females with an average age of 60.7 comprised the study population. The most common neoplasm encountered was plasma cell myeloma, followed by diffuse large B-cell lymphoma, B-lymphoblastic lymphoma, and follicular lymphoma. We encountered primarily intraosseous tumors, with the posterior mandible and posterior maxilla being the most common locations. Twelve cases were identified initially as a periapical radiolucency.
Our findings are concurrent with the existing literature regarding epidemiologic data. However, the type and location of tumors encountered do not, as the most common lymphoma in the oral cavity is diffuse large B-cell lymphoma, typically present in soft tissue. To aid in diagnosis and treatment, the collection of data should continue over time so that eventually, a more specific diagnostic profile of North Carolina residents with these neoplasms can be made.
根据美国北卡罗来纳州两家口腔颌面病理学机构的经验，报告口腔恶性血液系统肿瘤的发病率。
对东卡罗来纳大学牙科学院（ECU SoDM）和北卡罗来纳大学亚当斯牙科学院（UNC Adams SoD）患者的记录进行了为期10年的回顾性研究。记录了每个受试者的年龄、性别、病变部位、临床印象、初始诊断以及免疫组化和分子标志物的表达情况。所有诊断均根据2016年世界卫生组织淋巴肿瘤分类修订版进行复查。
共复查了两家机构的318份记录。研究人群包括70名男性和68名女性，平均年龄为60.7岁。最常见的肿瘤是浆细胞骨髓瘤，其次是弥漫性大B细胞淋巴瘤、B淋巴母细胞淋巴瘤和滤泡性淋巴瘤。我们主要遇到的是骨内肿瘤，下颌骨后部和上颌骨后部是最常见的部位。12例最初被诊断为根尖周透射区。
我们的研究结果与现有关于流行病学数据的文献一致。然而，所遇到肿瘤的类型和部位与口腔中最常见的淋巴瘤即弥漫性大B细胞淋巴瘤通常出现在软组织中的情况不同。为了有助于诊断和治疗，应持续收集数据，以便最终能够建立北卡罗来纳州这些肿瘤患者更具体的诊断特征。
